HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26618866
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 1480
+	Hs
		529568 ITCH_HUMAN (2187-2797): 8.94e-132: 440: 18.08		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		125126 WWP2_HUMAN (2430-2797): 2.93e-130: 435: 20.94		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529156 UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529592 NED4L_HUMAN (2187-2796): 1.96e-123: 418: 18.20		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528744 NEDD4_HUMAN (2446-2796): 8.62e-120: 416: 23.98		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529347 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529016 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		CFTR_HUMAN (1-1480): 0: 1031: 100.00