HitPredict

Interactor 1: UBR5 (O95071)
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)
Gene: UBR5

Interactor 2: HOOK1 (Q9UJC3)
Protein Hook homolog 1 (h-hook1) (hHK1)
Gene: HOOK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28718761
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2799 Hs			1 728
+	Hs
		304418 UBR5_HUMAN (1-2799): 0: 3949: 100.00		MYH4_HUMAN (2-633): 2.91e-28: 124: 12.23
+	Hs
		1072731 UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33		HOOK1_HUMAN (1-728): 8.51e-57: 208: 100.00
+	Hs
		1113852 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		GRDN_HUMAN (160-728): 9.47e-25: 113: 14.22
+	Hs
		1336100 SMUF1_HUMAN (2357-2796): 2.47e-141: 463: 21.18		DAPLE_HUMAN (33-676): 3.69e-18: 91.8: 11.43
+	Hs
		724841 UBE3C_HUMAN (2301-2796): 5.2e-128: 435: 20.33		MYH9_HUMAN (1-550): 5.58e-23: 107: 13.78
+	Hs
		1113845 WWP1_HUMAN (2180-2797): 2.84e-126: 425: 18.43		GRDN_HUMAN (160-728): 9.47e-25: 113: 14.22
+	Hs
		724896 HUWE1_HUMAN (2499-2798): 1.29e-100: 366: 27.27		MYH9_HUMAN (1-550): 5.58e-23: 107: 13.78
+	Mm
		1186481 HUWE1_MOUSE (2499-2798): 9.29e-101: 367: 27.27		HOOK3_MOUSE (216-727): 7.92e-13: 73.9: 11.17
+	Hs
		724789 UBE3A_HUMAN (2529-2799): 7.88e-20: 99.4: 29.93		MYH9_HUMAN (1-550): 5.58e-23: 107: 13.78