HitPredict

Interactor 1: GBRAP (O95166)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gene: GABARAP

Interactor 2: STK4 (Q13043)
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
Gene: STK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	31857374, 20562859
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 117 Hs			1 487
+	Hs
		891118 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		1023108 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		1023110 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		1023104 MLP3C_HUMAN (5-116): 1.15e-44: 143: 38.60		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		1023105 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		STK4_HUMAN (1-487): 7.89e-170: 489: 100.00
+	Hs
		891124 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	Hs
		306153 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	Hs
		1027427 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	Hs
		1027430 MLP3A_HUMAN (5-117): 2.29e-45: 144: 30.44		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	Hs
		1027422 MLP3C_HUMAN (5-116): 1.15e-44: 143: 38.60		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	Hs
		1027423 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		STK3_HUMAN (1-487): 2.36e-147: 432: 72.47
+	Hs
		568789 MLP3B_HUMAN (2-117): 3.54e-44: 141: 30.51		KAPCA_HUMAN (14-319): 7.68e-123: 364: 26.90
+	Hs
		891114 GBRL2_HUMAN (1-117): 2.75e-58: 176: 57.27		M4K2_HUMAN (17-316): 3.72e-75: 254: 42.67
+	Hs
		306141 GBRAP_HUMAN (1-117): 8.06e-57: 173: 100.00		M4K2_HUMAN (17-316): 3.72e-75: 254: 42.67
+	Hs
		1018189 GBRL1_HUMAN (1-116): 8.15e-56: 170: 87.07		M4K2_HUMAN (17-316): 3.72e-75: 254: 42.67