HitPredict

Interactor 1: KLHL2 (O95198)
Kelch-like protein 2 (Actin-binding protein Mayven)
Gene: KLHL2

Interactor 2: UBP28 (Q96RU2)
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)
Gene: USP28

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	31938050, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 1077
+	Hs
		1350370 KLHL9_HUMAN (14-588): 2.76e-161: 476: 26.86		UBP25_HUMAN (1-1068): 0: 977: 48.38
+	Hs
		1350482 KLH13_HUMAN (449-593): 6.27e-29: 123: 32.67		UBP25_HUMAN (1-1068): 0: 977: 48.38
+	Hs
		1120797 KLH12_HUMAN (30-592): 1.63e-174: 508: 41.70		USP9X_HUMAN (136-452): 1.14e-61: 233: 18.33
+	Dm
		1369132 Q9VK21_DROME (31-589): 1.15e-88: 288: 33.11		X2JLM6_DROME (397-649): 3.55e-12: 72.3: 12.65
+	Hs
		1049290 KEAP1_HUMAN (146-593): 8.68e-52: 189: 23.88		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		1049236 KEAP1_HUMAN (146-593): 8.68e-52: 189: 23.88		U17L2_HUMAN (446-745): 3.74e-21: 100: 13.49
+	Hs
		1273805 KLHL5_HUMAN (428-593): 6.92e-37: 148: 37.13		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		1273939 KLHL8_HUMAN (267-398): 9.63e-16: 82.5: 30.30		UBP7_HUMAN (547-839): 8.01e-23: 107: 20.13
+	Hs
		64225 KLH20_HUMAN (494-593): 2.37e-25: 112: 45.00		UBP27_HUMAN (562-658): 1.93e-11: 69.6: 22.68