HitPredict

Interactor 1: KLHL2 (O95198)
Kelch-like protein 2 (Actin-binding protein Mayven)
Gene: KLHL2

Interactor 2: TRIM8 (Q9BZR9)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 551
+	Hs
		307213 KLHL2_HUMAN (1-593): 0: 574: 100.00		TRIM9_HUMAN (45-397): 2.93e-56: 202: 16.30
+	Hs
		307204 KLHL2_HUMAN (1-593): 0: 574: 100.00		TRI47_HUMAN (13-298): 2.05e-50: 185: 21.28
+	Hs
		307193 KLHL2_HUMAN (1-593): 0: 574: 100.00		TRI50_HUMAN (9-252): 3.32e-13: 73.9: 23.36
+	Hs
		1049207 KEAP1_HUMAN (146-593): 8.68e-52: 189: 23.88		TRI25_HUMAN (8-365): 1.14e-59: 210: 22.31
+	Hs
		1299554 KLHL5_HUMAN (428-593): 6.92e-37: 148: 37.13		TRIM2_HUMAN (10-495): 3.74e-61: 216: 14.23
+	Hs
		1233687 KLH36_HUMAN (384-593): 1.42e-35: 143: 23.39		TRI63_HUMAN (2-347): 1.63e-59: 202: 19.67
+	Hs
		1233690 KLH36_HUMAN (384-593): 1.42e-35: 143: 23.39		TRI55_HUMAN (2-347): 8.15e-53: 190: 19.18
+	Hs
		1357688 KLH20_HUMAN (494-593): 2.37e-25: 112: 45.00		TRI33_HUMAN (14-534): 5.05e-61: 220: 14.95