HitPredict

Interactor 1: VENTX (O95231)
Homeobox protein VENTX (VENT homeobox homolog) (VENT-like homeobox protein 2)
Gene: VENTX

Interactor 2: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 258 Hs			1 743
+	Hs
		308077 VENTX_HUMAN (1-258): 5.22e-42: 145: 100.00		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		308074 VENTX_HUMAN (1-258): 5.22e-42: 145: 100.00		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Mm
		623700 PAX3_MOUSE (65-249): 1.51e-31: 123: 21.26		TLE4_MOUSE (1-743): 1.35e-176: 526: 65.93
+	Hs
		641379 PAX6_HUMAN (8-250): 1.68e-31: 121: 20.17		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		980936 ISX_HUMAN (77-237): 5.93e-33: 121: 29.09		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		308076 VENTX_HUMAN (1-258): 5.22e-42: 145: 100.00		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Hs
		641377 PAX6_HUMAN (8-250): 1.68e-31: 121: 20.17		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		980618 ISX_HUMAN (77-237): 5.93e-33: 121: 29.09		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		641378 PAX6_HUMAN (8-250): 1.68e-31: 121: 20.17		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Hs
		980762 ISX_HUMAN (77-237): 5.93e-33: 121: 29.09		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Hs
		308095 VENTX_HUMAN (1-258): 5.22e-42: 145: 100.00		Q5T3G3_HUMAN (1-223): 3.33e-115: 349: 60.00
+	Hs
		308093 VENTX_HUMAN (1-258): 5.22e-42: 145: 100.00		Q5JSZ1_HUMAN (1-188): 5.44e-109: 332: 64.46
+	Hs
		308078 VENTX_HUMAN (1-258): 5.22e-42: 145: 100.00		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		837946 MEOX2_HUMAN (52-154): 8.49e-35: 128: 35.92		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		641385 PAX6_HUMAN (8-250): 1.68e-31: 121: 20.17		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		993441 ISX_HUMAN (77-237): 5.93e-33: 121: 29.09		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Mm
		192307 ALX4_MOUSE (10-248): 9.61e-32: 122: 19.20		TLE6_MOUSE (444-743): 4.72e-48: 181: 34.31
+	Hs
		245563 PAX6_HUMAN (8-250): 1.68e-31: 121: 20.17		TBL1X_HUMAN (542-742): 1.23e-45: 174: 15.60
+	Hs
		837910 MEOX2_HUMAN (52-154): 8.49e-35: 128: 35.92		WDR5_HUMAN (628-742): 1.63e-35: 139: 21.37
+	Hs
		903301 Q6FHY5_HUMAN (52-154): 8.3e-35: 128: 35.92		WDR5_HUMAN (628-742): 1.63e-35: 139: 21.37