HitPredict

Interactor 1: MTMR5 (O95248)
Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1)
Gene: SBF1

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DENN~Ras, PH~Ras, Ras~uDENN
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1868 Hs			1 193
+	Hs
		309467 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		309429 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		309470 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		309459 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		309435 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		309458 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		309466 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120255 MTMR5_HUMAN (1-1868): 0: 2532: 100.00		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		900451 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925261 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		950979 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		893983 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545361 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		892358 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		915659 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120424 MTMR1_HUMAN (1097-1647): 3.3e-152: 486: 22.56		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		925348 DEN4C_HUMAN (22-573): 8.87e-127: 443: 21.03		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		120487 DEN4C_HUMAN (22-573): 8.87e-127: 443: 21.03		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		915752 DEN2C_HUMAN (3-473): 4.5e-103: 356: 19.96		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		925666 MTMRA_HUMAN (1358-1573): 1.99e-24: 113: 34.38		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22