Protein: SYP
Proline--tRNA ligase (EC 6.1.1.15) (Global RNA synthesis factor) (Prolyl-tRNA synthetase) (ProRS)

Gene: SYP, proS
Organism: Escherichia coli K-12
Interactions: 22
UniProt ID: P16659

Gene Ontology (top 5):
GO:0004827 - proline-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006433 - prolyl-tRNA aminoacylation
GO:0043906 - Ala-tRNA(Pro) deacylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

450076

PROA
Gamma-glutamyl phosphate reductase

2

2

High-throughput

0.618

High

598488

SYP
Proline--tRNA ligase

1

15

High-throughput

0.618

High

498506

DYR
Dihydrofolate reductase

2

1

High-throughput

0.588

High

489669

CH60
Chaperonin GroEL

1

3

High-throughput

0.515

High

500793

ODP1
Pyruvate dehydrogenase E1 component

1

0

High-throughput

0.513

High

598491

NARQ
Nitrate/nitrite sensor protein NarQ

1

0

High-throughput

0.513

High

598492

TREC
Trehalose-6-phosphate hydrolase

1

0

High-throughput

0.513

High

420129

FLIC
Flagellin

1

2

High-throughput

0.489

High

598495

LSRK
Autoinducer-2 kinase

1

1

High-throughput

0.489

High

491131

DNAK
Chaperone protein DnaK

1

7

High-throughput

0.484

High

501706

IBPA
Small heat shock protein IbpA

1

1

High-throughput

0.484

High

598494

CLPB
Chaperone protein ClpB

1

4

Small-scale

0.479

High

496359

DPO3B
Beta sliding clamp

1

0

High-throughput

0.464

High

501054

RPE
Ribulose-phosphate 3-epimerase

1

1

High-throughput

0.457

High

598493

FLII
Flagellum-specific ATP synthase

1

3

High-throughput

0.457

High

456998

CHEA
Chemotaxis protein CheA

1

0

High-throughput

0.438

High

500351

FLIA
RNA polymerase sigma factor FliA

1

0

High-throughput

0.438

High

598489

CYSI
Sulfite reductase [NADPH] hemoprotein beta-component

1

0

High-throughput

0.279

Low

598490

WECG
UDP-N-acetyl-D-mannosaminuronic acid transferase

1

0

High-throughput

0.279

Low

498724

FLIG
Flagellar motor switch protein FliG

1

0

High-throughput

0.238

Low

578591

FLIN
Flagellar motor switch protein FliN

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025