HitPredict

Interactor 1: LCA5L (O95447)
Lebercilin-like protein (Leber congenital amaurosis 5-like protein)
Gene: LCA5L

Interactor 2: TPM3 (P06753)
Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
Gene: TPM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.573

Property	Details
Experiments	25416956, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 670 Hs			1 285
+	Hs
		314515 LCA5L_HUMAN (1-670): 5.38e-89: 293: 100.00		Q5VU62_HUMAN (128-285): 1.66e-39: 137: 100.00
+	Hs
		1137917 MRCKA_HUMAN (114-515): 5.41e-47: 181: 14.69		MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92
+	Hs
		419011 MY18A_HUMAN (74-521): 7.48e-18: 90.5: 10.06		TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00
+	Hs
		451293 MY18A_HUMAN (74-521): 7.48e-18: 90.5: 10.06		TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20
+	Hs
		419054 MYO5C_HUMAN (82-535): 1.25e-15: 83.1: 12.73		TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00
+	Hs
		434415 MY18A_HUMAN (74-521): 7.48e-18: 90.5: 10.06		TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27
+	Hs
		418895 MYH9_HUMAN (1-580): 2.72e-13: 75.8: 10.49		TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00
+	Hs
		451201 MYH9_HUMAN (1-580): 2.72e-13: 75.8: 10.49		TPM1_HUMAN (2-285): 2.54e-44: 153: 91.20
+	Hs
		434437 MYO5C_HUMAN (82-535): 1.25e-15: 83.1: 12.73		TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27
+	Hs
		148289 CTRO_HUMAN (77-514): 2.04e-11: 69.7: 9.34		TPM3_HUMAN (1-285): 3.63e-44: 153: 100.00
+	Hs
		434354 MYH9_HUMAN (1-580): 2.72e-13: 75.8: 10.49		TPM2_HUMAN (2-285): 1.42e-39: 141: 86.27
+	Hs
		932031 MY18A_HUMAN (74-521): 7.48e-18: 90.5: 10.06		TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96
+	Hs
		724765 MYH9_HUMAN (1-580): 2.72e-13: 75.8: 10.49		TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96
+	Hs
		148661 CTRO_HUMAN (77-514): 2.04e-11: 69.7: 9.34		TPM4_HUMAN (43-285): 1.76e-33: 124: 69.96
+	Hs
		1268126 MY18A_HUMAN (74-521): 7.48e-18: 90.5: 10.06		MRCKB_HUMAN (12-285): 1.02e-11: 67.2: 14.92
+	Rn
		1186812 MRCKB_RAT (69-471): 4.08e-16: 85.1: 10.23		MRCKB_RAT (3-285): 1.56e-12: 69.5: 14.09
+	Hs
		110802 MY18A_HUMAN (74-521): 7.48e-18: 90.5: 10.06		H7BYY1_HUMAN (2-228): 1.39e-10: 62.2: 21.37
+	Rn
		222476 MRCKA_RAT (42-469): 1.37e-15: 83.2: 10.48		MRCKB_RAT (3-285): 1.56e-12: 69.5: 14.09
+	Hs
		110796 MYH9_HUMAN (1-580): 2.72e-13: 75.8: 10.49		H7BYY1_HUMAN (2-228): 1.39e-10: 62.2: 21.37