Protein: PHF2
Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)

Gene: PHF2
Organism: Homo sapiens
Interactions: 74
UniProt ID: O75151

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0001889 - liver development
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005506 - iron ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

272830

H2B2E
Histone H2B type 2-E

2

19

High-throughput

0.802

High

272810

H2B1C
Histone H2B type 1-C/E/F/G/I

2

19

High-throughput

0.754

High

272790

H2AZ
Histone H2A.Z

1

12

High-throughput

0.691

High

272825

ARI5B
AT-rich interactive domain-containing protein 5B

1

5

Small-scale

0.647

High

272794

NELFE
Negative elongation factor E

1

1

High-throughput

0.618

High

272796

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.618

High

272803

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

272814

H31
Histone H3.1

1

20

High-throughput

0.618

High

272815

H33
Histone H3.3

1

20

High-throughput

0.618

High

272827

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.618

High

272829

H31T
Histone H3.1t

1

20

Small-scale

0.618

High

272831

LARP7
La-related protein 7

1

5

High-throughput

0.618

High

272833

H32
Histone H3.2

1

20

Small-scale

0.618

High

272848

PHF8
Histone lysine demethylase PHF8

1

11

High-throughput

0.575

High

272785

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

130328

SPT5H
Transcription elongation factor SPT5

1

12

High-throughput

0.536

High

272784

FRIL
Ferritin light chain

1

3

High-throughput

0.536

High

272820

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

272843

NR1H4
Bile acid receptor

1

20

Small-scale

0.516

High

272840

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.513

High

272801

HNF4A
Hepatocyte nuclear factor 4-alpha

1

19

Small-scale

0.501

High

271202

CPNE3
Copine-3

1

0

High-throughput

0.493

High

140682

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

142747

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.479

High

156759

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

190759

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

6

High-throughput

0.479

High

254316

CC14B
Dual specificity protein phosphatase CDC14B

1

4

High-throughput

0.479

High

272786

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

272787

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.479

High

272788

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

272789

PARP1
Poly [ADP-ribose] polymerase 1

1

16

High-throughput

0.479

High

272791

XRCC6
X-ray repair cross-complementing protein 6

1

5

High-throughput

0.479

High

272792

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

272797

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

272798

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

High-throughput

0.479

High

272799

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

272800

COIL
Coilin

1

2

High-throughput

0.479

High

272802

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

272804

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.479

High

272805

LHX2
LIM/homeobox protein Lhx2

1

5

High-throughput

0.479

High

272806

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

272807

FOXA1
Hepatocyte nuclear factor 3-alpha

1

5

High-throughput

0.479

High

272809

H4
Histone H4

1

10

High-throughput

0.479

High

272811

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

272812

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

272813

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.479

High

272816

VIGLN
Vigilin

1

4

High-throughput

0.479

High

272817

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

9

High-throughput

0.479

High

272819

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

272821

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

272822

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

272823

CUL3
Cullin-3

1

6

High-throughput

0.479

High

272826

SUZ12
Polycomb protein SUZ12

1

1

Small-scale

0.479

High

272828

EEA1
Early endosome antigen 1

1

7

High-throughput

0.479

High

272832

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

272834

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

272835

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

272836

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

3

Small-scale

0.479

High

272838

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

272839

STAG2
Cohesin subunit SA-2

1

1

High-throughput

0.479

High

272841

NUP43
Nucleoporin Nup43

1

19

High-throughput

0.479

High

272842

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

272844

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

272845

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.479

High

272846

MLXPL
Carbohydrate-responsive element-binding protein

1

3

Small-scale

0.479

High

272847

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

272849

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

272850

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

272793

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

272808

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

272795

NEBU
Nebulin

1

4

High-throughput

0.437

High

272818

RL18A
Large ribosomal subunit protein eL20

1

1

High-throughput

0.437

High

272837

DHX40
Probable ATP-dependent RNA helicase DHX40

1

6

High-throughput

0.437

High

272824

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025