HitPredict

Interactor 1: FMNL1 (O95466)
Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin)
Gene: FMNL1

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0016477 - cell migration GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1100 Hs			1 193
+	Hs
		314858 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		314860 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		314853 FMNL1_HUMAN (1-1100): 0: 849: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		314838 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		900815 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925531 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		314856 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		436466 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		894328 FMNL2_HUMAN (1-1097): 0: 834: 57.31		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		120260 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Hs
		915901 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120589 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98
+	Dm
		776921 FRL_DROME (19-1088): 0: 650: 36.85		RAC1_DROME (1-193): 2.11e-77: 231: 54.12
+	Dm
		776944 FRL_DROME (19-1088): 0: 650: 36.85		CDC42_DROME (1-193): 4.33e-75: 225: 51.30
+	Hs
		925768 FHOD1_HUMAN (185-1099): 1.49e-138: 449: 16.22		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		894633 FHOD1_HUMAN (185-1099): 1.49e-138: 449: 16.22		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		900661 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		894190 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		545484 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		120464 INF2_HUMAN (181-1063): 2.53e-120: 402: 20.27		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98