Protein: SEM1
26S proteasome complex subunit SEM1

Gene: SEM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 91
UniProt ID: O94742

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0000724 - double-strand break repair via homologous recombination
GO:0005829 - cytosol
GO:0006406 - mRNA export from nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

314910

RPN7
26S proteasome regulatory subunit RPN7

10

1

Small-scale

0.972

High

314915

RPN5
26S proteasome regulatory subunit RPN5

7

1

Small-scale

0.956

High

314884

SAC3
Nuclear mRNA export protein SAC3

6

1

Small-scale

0.932

High

314912

THP1
Nuclear mRNA export protein THP1

5

2

Small-scale

0.916

High

314875

RPN3
26S proteasome regulatory subunit RPN3

8

0

Small-scale

0.912

High

314908

RPN9
26S proteasome regulatory subunit RPN9

5

0

Small-scale

0.865

High

314916

RPN6
26S proteasome regulatory subunit RPN6

5

0

Small-scale

0.865

High

314887

CSN12
Cop9 signalosome complex subunit 12

6

1

Small-scale

0.842

High

314914

THP3
Protein THP3

3

1

Small-scale

0.770

High

314881

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

16

1

Small-scale

0.760

High

314868

RPN1
26S proteasome regulatory subunit RPN1

6

1

Small-scale

0.729

High

314902

PRS8
26S proteasome regulatory subunit 8 homolog

6

2

Small-scale

0.724

High

314860

PRS7
26S proteasome regulatory subunit 7 homolog

5

2

Small-scale

0.709

High

314854

RPN2
26S proteasome regulatory subunit RPN2

5

1

Small-scale

0.706

High

314897

PRS10
26S proteasome subunit RPT4

5

2

Small-scale

0.706

High

314859

PRS6B
26S proteasome regulatory subunit 6B homolog

4

1

Small-scale

0.683

High

314878

PRS4
26S proteasome regulatory subunit 4 homolog

4

2

Small-scale

0.683

High

314853

RPN12
26S proteasome regulatory subunit RPN12

5

0

Small-scale

0.679

High

314858

PRS6A
26S proteasome regulatory subunit 6A

5

0

Small-scale

0.676

High

314913

RPN8
26S proteasome regulatory subunit RPN8

5

0

Small-scale

0.676

High

314870

RPN10
26S proteasome regulatory subunit RPN10

4

0

Small-scale

0.653

High

314841

PSB4
Proteasome subunit beta type-4

3

2

Small-scale

0.650

High

314865

HSM3
DNA mismatch repair protein HSM3

4

0

Small-scale

0.648

High

314890

PSD10
Probable 26S proteasome regulatory subunit p28

3

0

High-throughput

0.634

High

314918

SUS1
SAGA complex subunit SUS1

3

0

Small-scale

0.628

High

150243

RPN13
26S proteasome regulatory subunit RPN13

3

0

Small-scale

0.622

High

314843

PSA2
Proteasome subunit alpha type-2

2

1

High-throughput

0.584

High

314857

RAD23
UV excision repair protein RAD23

2

0

High-throughput

0.576

High

314882

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

2

0

High-throughput

0.576

High

314877

PSA6
Proteasome subunit alpha type-6

2

0

High-throughput

0.559

High

314896

RPN14
26S proteasome regulatory subunit RPN14

2

0

High-throughput

0.559

High

314864

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.518

High

314901

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.515

High

314829

CDC31
Cell division control protein 31

1

0

High-throughput

0.493

High

314837

SEC18
Vesicular-fusion protein SEC18

1

0

High-throughput

0.493

High

314838

DDR48
Stress protein DDR48

1

0

High-throughput

0.493

High

314863

SQT1
Ribosome assembly protein SQT1

1

0

High-throughput

0.493

High

314873

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.493

High

314885

TRS85
Trafficking protein particle complex III-specific subunit 85

1

0

High-throughput

0.493

High

314830

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

314836

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

314844

PSB6
Proteasome subunit beta type-6

1

2

High-throughput

0.479

High

314845

PSB2
Proteasome subunit beta type-2

1

1

High-throughput

0.479

High

314848

PSB3
Proteasome subunit beta type-3

1

1

High-throughput

0.479

High

314866

PSB1
Proteasome subunit beta type-1

1

2

High-throughput

0.479

High

314840

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.458

High

314842

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.458

High

314867

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

314879

MLP2
Protein MLP2

1

0

High-throughput

0.458

High

314891

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

Small-scale

0.458

High

314894

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.458

High

314899

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.458

High

314904

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

314905

RPN4
Protein RPN4

1

0

Small-scale

0.458

High

314909

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

314831

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

314832

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

314833

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

314846

SIS1
Protein SIS1

1

1

High-throughput

0.445

High

314849

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

314855

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

314856

HSP79
Heat shock protein homolog SSE2

1

3

High-throughput

0.445

High

314872

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

314876

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

314880

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.445

High

314898

JJJ1
J protein JJJ1

1

1

High-throughput

0.445

High

314835

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.426

High

314869

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

314874

HSP7E
Heat shock protein SSC3, mitochondrial

1

0

High-throughput

0.426

High

314911

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.426

High

314847

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.407

High

314883

ERJ5
ER-localized J domain-containing protein 5

1

3

High-throughput

0.407

High

314889

HLJ1
Protein HLJ1

1

1

High-throughput

0.407

High

314892

CWC23
Pre-mRNA-splicing factor CWC23

1

1

High-throughput

0.407

High

314839

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.269

Low

314850

DPO4
DNA polymerase IV

1

0

High-throughput

0.269

Low

314862

TOD6
Transcriptional regulatory protein TOD6

1

0

High-throughput

0.269

Low

314888

TCB2
Tricalbin-2

1

0

High-throughput

0.269

Low

314893

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.269

Low

314900

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

0

High-throughput

0.269

Low

314917

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.251

Low

314851

PRR1
Serine/threonine-protein kinase PRR1

1

0

High-throughput

0.249

Low

314852

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

314903

ADA2
SAGA complex subunit ADA2

1

0

Small-scale

0.249

Low

314906

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

314907

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low

314834

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

314861

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

314871

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.232

Low

314886

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

314895

JAC1
J-type co-chaperone JAC1, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025