HitPredict

Interactor 1: FMNL1 (O95466)
Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin)
Gene: FMNL1

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0008360 - regulation of cell shape GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1100 Hs			1 191
+	Hs
		314856 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		436466 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		915901 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		314858 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		314853 FMNL1_HUMAN (1-1100): 0: 849: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		314838 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		314860 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		314854 FMNL1_HUMAN (1-1100): 0: 849: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		925531 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		894328 FMNL2_HUMAN (1-1097): 0: 834: 57.31		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		900815 FMNL2_HUMAN (1-1097): 0: 834: 57.31		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Dm
		776921 FRL_DROME (19-1088): 0: 650: 36.85		RAC1_DROME (2-191): 5.11e-73: 220: 38.58
+	Dm
		776944 FRL_DROME (19-1088): 0: 650: 36.85		CDC42_DROME (2-191): 7.23e-71: 214: 40.10
+	Hs
		925768 FHOD1_HUMAN (185-1099): 1.49e-138: 449: 16.22		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		894633 FHOD1_HUMAN (185-1099): 1.49e-138: 449: 16.22		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		436333 INF2_HUMAN (181-1063): 2.53e-120: 402: 20.27		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		894190 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545484 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		900661 FMNL3_HUMAN (1-506): 6.36e-130: 423: 60.90		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		545409 INF2_HUMAN (181-1063): 2.53e-120: 402: 20.27		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07