HitPredict

Interactor 1: SIX6 (O95475)
Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6)
Gene: SIX6

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.626

Property	Details
Experiments	12441302, 33961781
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 197
+	Hs
		315171 SIX6_HUMAN (1-246): 3.72e-97: 285: 100.00		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		315169 SIX6_HUMAN (1-246): 3.72e-97: 285: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Mm
		1143964 SIX6_MOUSE (1-246): 8.09e-93: 274: 97.97		TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59
+	Mm
		1143691 SIX3_MOUSE (1-246): 4.34e-90: 270: 77.95		TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59
+	Hs
		311439 SIX3_HUMAN (1-246): 1.05e-89: 270: 77.95		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		315170 SIX6_HUMAN (1-246): 3.72e-97: 285: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980654 SIX2_HUMAN (1-224): 1.11e-89: 268: 60.35		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980881 SIX2_HUMAN (1-224): 1.11e-89: 268: 60.35		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980756 SIX1_HUMAN (1-245): 3.48e-87: 262: 51.34		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Mm
		925832 SIX6_MOUSE (1-246): 8.09e-93: 274: 97.97		TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49
+	Hs
		311440 SIX3_HUMAN (1-246): 1.05e-89: 270: 77.95		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Mm
		925828 SIX3_MOUSE (1-246): 4.34e-90: 270: 77.95		TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49
+	Hs
		993614 SIX2_HUMAN (1-224): 1.11e-89: 268: 60.35		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		1132994 SIX2_HUMAN (1-224): 1.11e-89: 268: 60.35		Q5T3G3_HUMAN (2-197): 1.07e-99: 290: 61.43
+	Hs
		993432 SIX1_HUMAN (1-245): 3.48e-87: 262: 51.34		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		620142 PAX7_HUMAN (127-243): 4.13e-34: 129: 23.93		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Dm
		558378 SO_DROME (4-233): 4.43e-83: 255: 55.22		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Dm
		558386 OPTIX_DROME (1-246): 8.68e-74: 233: 56.81		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Hs
		993568 PITX2_HUMAN (26-222): 4.04e-38: 136: 19.80		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Ce
		137686 HM32_CAEEL (5-246): 6.12e-67: 215: 52.07		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47