HitPredict

Interactor 1: CBX6 (O95503)
Chromobox protein homolog 6
Gene: CBX6

Interactor 2: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 412 Hs			1 619
+	Hs
		727806 CBX8_HUMAN (1-393): 2.31e-76: 243: 30.82		SOX5_HUMAN (3-485): 3.95e-38: 152: 12.73
+	Hs
		1027280 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		TF7L2_HUMAN (1-619): 4e-84: 277: 100.00
+	Hs
		996854 MPP8_HUMAN (6-339): 4.19e-48: 177: 14.91		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Hs
		800501 CBX5_HUMAN (11-106): 3.1e-28: 111: 29.17		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		123201 CBX4_HUMAN (1-362): 3.71e-34: 135: 23.28		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		1027207 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Dm
		1363173 Q9VCU6_DROME (8-202): 2.25e-26: 107: 19.10		Q9VUD3_DROME (302-514): 2.02e-31: 131: 19.07
+	Hs
		331801 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		NSD2_HUMAN (251-564): 1.22e-30: 130: 13.97
+	Dm
		114467 Q9VCU6_DROME (8-202): 2.25e-26: 107: 19.10		M9PCG2_DROME (302-514): 6.35e-30: 126: 19.07
+	Mm
		818718 CBX5_MOUSE (11-106): 1.59e-27: 109: 29.17		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15
+	Hs
		996646 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Mm
		818771 Q9DCC5_MOUSE (9-121): 1.26e-25: 104: 24.56		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15
+	Mm
		818693 CBX1_MOUSE (17-85): 6.16e-23: 97.1: 34.78		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15
+	Hs
		996672 CBX2_HUMAN (161-394): 3.76e-13: 72.9: 21.46		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Hs
		818053 CBX2_HUMAN (161-394): 3.76e-13: 72.9: 21.46		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		175775 CBX3_HUMAN (9-121): 1.26e-25: 104: 24.56		HMGB3_HUMAN (354-438): 3.21e-09: 59.2: 17.24