Protein: BLM
RecQ-like DNA helicase BLM (EC 5.6.2.4) (Bloom syndrome protein) (DNA 3'-5' helicase BLM) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)

Gene: BLM
Organism: Homo sapiens
Interactions: 211
UniProt ID: P54132

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000228 - nuclear chromosome
GO:0000400 - four-way junction DNA binding
GO:0000403 - Y-form DNA binding
GO:0000405 - bubble DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926347

TOP3A
DNA topoisomerase 3-alpha

13

11

Small-scale

0.983

High

926379

FANCM
Fanconi anemia group M protein

5

19

Small-scale

0.915

High

926390

FBXW7
F-box/WD repeat-containing protein 7

2

18

Small-scale

0.834

High

926375

MIB1
E3 ubiquitin-protein ligase MIB1

2

6

Small-scale

0.812

High

855411

ATRX
Transcriptional regulator ATRX

2

20

Small-scale

0.806

High

926404

FANCJ
Fanconi anemia group J protein

2

0

Small-scale

0.801

High

926355

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

19

Small-scale

0.761

High

413470

P53
Cellular tumor antigen p53

11

5

Small-scale

0.757

High

695020

RFA1
Replication protein A 70 kDa DNA-binding subunit

12

11

Small-scale

0.756

High

926311

BLM
RecQ-like DNA helicase BLM

2

17

Small-scale

0.754

High

926337

RAD51
DNA repair protein RAD51 homolog 1

9

14

Small-scale

0.754

High

926415

RMI1
RecQ-mediated genome instability protein 1

9

4

Small-scale

0.753

High

827357

MLH1
DNA mismatch repair protein Mlh1

7

3

Small-scale

0.751

High

588293

RFA2
Replication protein A 32 kDa subunit

7

11

Small-scale

0.737

High

767782

RFA3
Replication protein A 14 kDa subunit

6

7

Small-scale

0.724

High

926396

RMI2
RecQ-mediated genome instability protein 2

9

0

Small-scale

0.722

High

509960

TRI49
Tripartite motif-containing protein 49

1

6

Small-scale

0.692

High

371557

MYC
Myc proto-oncogene protein

4

12

Small-scale

0.692

High

926313

CORO7
Coronin-7

1

11

High-throughput

0.691

High

187491

FANCA
Fanconi anemia group A protein

5

0

Small-scale

0.678

High

926361

TERF2
Telomeric repeat-binding factor 2

3

4

Small-scale

0.678

High

798892

BRCA1
Breast cancer type 1 susceptibility protein

4

19

Small-scale

0.672

High

926386

TOPB1
DNA topoisomerase 2-binding protein 1

3

12

Small-scale

0.667

High

926437

EXO1
Exonuclease 1

3

2

Small-scale

0.667

High

926364

RIF1
Telomere-associated protein RIF1

3

7

Small-scale

0.667

High

904497

MECP2
Methyl-CpG-binding protein 2

3

13

High-throughput

0.667

High

926344

ATM
Serine-protein kinase ATM

3

10

Small-scale

0.660

High

926406

FACD2
Fanconi anemia group D2 protein

3

9

Small-scale

0.650

High

926340

TP53B
TP53-binding protein 1

3

7

Small-scale

0.646

High

814494

FEN1
Flap endonuclease 1

2

2

Small-scale

0.646

High

926329

H31
Histone H3.1

3

16

High-throughput

0.640

High

926388

RAD50
DNA repair protein RAD50

3

10

Small-scale

0.633

High

429577

JUN
Transcription factor Jun

2

13

Small-scale

0.629

High

926398

ZN512
Zinc finger protein 512

2

2

High-throughput

0.628

High

926425

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

2

2

High-throughput

0.628

High

926330

RNF4
E3 ubiquitin-protein ligase RNF4

2

3

Small-scale

0.624

High

892828

MRE11
Double-strand break repair protein MRE11

3

3

Small-scale

0.624

High

926416

RENT2
Regulator of nonsense transcripts 2

1

1

High-throughput

0.621

High

302440

RNF8
E3 ubiquitin-protein ligase RNF8

2

8

Small-scale

0.619

High

262045

NBN
Nibrin

2

4

Small-scale

0.619

High

542399

TOP2A
DNA topoisomerase 2-alpha

1

1

Small-scale

0.618

High

807327

IF4A3
Eukaryotic initiation factor 4A-III

1

19

High-throughput

0.618

High

926315

MGN
Protein mago nashi homolog

1

4

High-throughput

0.618

High

926331

RED1
Double-stranded RNA-specific editase 1

1

18

High-throughput

0.618

High

926351

PWP1
Periodic tryptophan protein 1 homolog

1

20

Small-scale

0.618

High

926356

DHX8
ATP-dependent RNA helicase DHX8

1

14

High-throughput

0.618

High

926360

RBBP5
Retinoblastoma-binding protein 5

1

20

High-throughput

0.618

High

926376

DHX40
Probable ATP-dependent RNA helicase DHX40

1

16

High-throughput

0.618

High

926384

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

926391

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

20

High-throughput

0.618

High

926395

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

18

High-throughput

0.618

High

926401

TEP1
Telomerase protein component 1

1

20

Small-scale

0.618

High

926419

NLE1
Notchless protein homolog 1

1

13

High-throughput

0.618

High

926380

CENPS
Centromere protein S

3

0

Small-scale

0.613

High

919831

PLK1
Serine/threonine-protein kinase PLK1

2

9

Small-scale

0.612

High

926350

KRR1
KRR1 small subunit processome component homolog

2

3

High-throughput

0.601

High

292338

RA51D
DNA repair protein RAD51 homolog 4

1

14

Small-scale

0.594

High

487127

PARP1
Poly [ADP-ribose] polymerase 1

2

9

Small-scale

0.584

High

591552

H2AX
Histone H2AX

2

7

Small-scale

0.584

High

926378

SLX4
Structure-specific endonuclease subunit SLX4

2

13

High-throughput

0.584

High

220056

XRCC2
DNA repair protein XRCC2

1

14

Small-scale

0.578

High

926372

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

12

Small-scale

0.578

High

926363

ERC6L
DNA excision repair protein ERCC-6-like

1

18

High-throughput

0.575

High

926341

CAF1A
Chromatin assembly factor 1 subunit A

1

5

Small-scale

0.573

High

926354

SPIDR
DNA repair-scaffolding protein

1

0

Small-scale

0.571

High

395749

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

846570

MSH2
DNA mismatch repair protein Msh2

2

7

Small-scale

0.571

High

913286

MSH6
DNA mismatch repair protein Msh6

2

7

Small-scale

0.571

High

840652

RS27
Small ribosomal subunit protein eS27

1

2

Small-scale

0.569

High

926348

ATR
Serine/threonine-protein kinase ATR

1

11

Small-scale

0.561

High

926367

RN111
E3 ubiquitin-protein ligase Arkadia

1

5

Small-scale

0.561

High

926312

TERF1
Telomeric repeat-binding factor 1

1

4

Small-scale

0.554

High

926431

HECD1
E3 ubiquitin-protein ligase HECTD1

1

16

High-throughput

0.553

High

926328

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.552

High

191574

MAGB2
Melanoma-associated antigen B2

1

9

High-throughput

0.536

High

245682

GANP
Germinal-center associated nuclear protein

1

1

High-throughput

0.536

High

502276

H2A1
Histone H2A type 1

1

6

High-throughput

0.536

High

570862

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

633635

PSB1
Proteasome subunit beta type-1

1

10

High-throughput

0.536

High

698246

MAP4
Microtubule-associated protein 4

1

14

High-throughput

0.536

High

788607

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

858851

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

908904

NEK4
Serine/threonine-protein kinase Nek4

1

6

High-throughput

0.536

High

926317

RS16
Small ribosomal subunit protein uS9

1

5

High-throughput

0.536

High

926318

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.536

High

926332

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.536

High

926334

RBM3
RNA-binding protein 3

1

20

High-throughput

0.536

High

926352

NOG2
Nucleolar GTP-binding protein 2

1

5

High-throughput

0.536

High

926357

CASP8
Caspase-8

1

5

High-throughput

0.536

High

926362

H2B2E
Histone H2B type 2-E

1

8

High-throughput

0.536

High

926374

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

10

High-throughput

0.536

High

926389

CSN5
COP9 signalosome complex subunit 5

1

17

High-throughput

0.536

High

926410

FOXP1
Forkhead box protein P1

1

6

High-throughput

0.536

High

926420

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

6

High-throughput

0.536

High

926430

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.536

High

926432

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

884002

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

926369

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

926371

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

926382

ZBT44
Zinc finger and BTB domain-containing protein 44

1

0

High-throughput

0.513

High

926409

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

926412

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

926418

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

926436

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.513

High

840024

CASP3
Caspase-3

1

5

Small-scale

0.501

High

903057

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

8

Small-scale

0.501

High

926385

NEK11
Serine/threonine-protein kinase Nek11

1

10

Small-scale

0.501

High

926399

UIMC1
BRCA1-A complex subunit RAP80

1

0

Small-scale

0.493

High

926439

FAN1
Fanconi-associated nuclease 1

1

0

Small-scale

0.493

High

657218

KALM
Anosmin-1

1

2

High-throughput

0.489

High

210897

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

Small-scale

0.481

High

605511

SYN1
Synapsin-1

1

8

Small-scale

0.481

High

633362

MX1
Interferon-induced GTP-binding protein Mx1

1

2

Small-scale

0.481

High

926316

SUMO2
Small ubiquitin-related modifier 2

1

9

Small-scale

0.481

High

926325

SUMO1
Small ubiquitin-related modifier 1

1

9

Small-scale

0.481

High

926402

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.479

High

127033

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

Small-scale

0.479

High

140824

NOP56
Nucleolar protein 56

1

2

High-throughput

0.479

High

159577

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

163073

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

190861

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

6

High-throughput

0.479

High

241188

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

259677

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

262501

MCE1
mRNA-capping enzyme

1

5

High-throughput

0.479

High

330785

KI20A
Kinesin-like protein KIF20A

1

14

High-throughput

0.479

High

342804

HERC2
E3 ubiquitin-protein ligase HERC2

1

13

Small-scale

0.479

High

349892

SNAI1
Zinc finger protein SNAI1

1

5

High-throughput

0.479

High

363024

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

418897

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

461305

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

519352

MYB
Transcriptional activator Myb

1

6

High-throughput

0.479

High

557982

XRCC6
X-ray repair cross-complementing protein 6

1

10

High-throughput

0.479

High

596007

H12
Histone H1.2

1

4

High-throughput

0.479

High

609970

VGFR1
Vascular endothelial growth factor receptor 1

1

4

High-throughput

0.479

High

679112

DNJB1
DnaJ homolog subfamily B member 1

1

4

High-throughput

0.479

High

713970

PML
Protein PML

1

18

High-throughput

0.479

High

799815

COIL
Coilin

1

1

High-throughput

0.479

High

832505

ETV3
ETS translocation variant 3

1

3

High-throughput

0.479

High

833904

HNF4A
Hepatocyte nuclear factor 4-alpha

1

18

High-throughput

0.479

High

877506

LHX1
LIM/homeobox protein Lhx1

1

2

High-throughput

0.479

High

883489

CENPA
Histone H3-like centromeric protein A

1

16

High-throughput

0.479

High

886255

ARL4D
ADP-ribosylation factor-like protein 4D

1

6

High-throughput

0.479

High

895695

LHX2
LIM/homeobox protein Lhx2

1

2

High-throughput

0.479

High

926319

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

926320

H4
Histone H4

1

7

High-throughput

0.479

High

926321

H2B1C
Histone H2B type 1-C/E/F/G/I

1

8

High-throughput

0.479

High

926322

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.479

High

926323

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.479

High

926324

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

11

High-throughput

0.479

High

926326

DYL1
Dynein light chain 1, cytoplasmic

1

1

Small-scale

0.479

High

926333

H33
Histone H3.3

1

16

High-throughput

0.479

High

926336

HEN1
Helix-loop-helix protein 1

1

2

High-throughput

0.479

High

926338

ARL16
ADP-ribosylation factor-like protein 16

1

7

High-throughput

0.479

High

926342

RFA4
Replication protein A 30 kDa subunit

1

11

High-throughput

0.479

High

926343

CBX3
Chromobox protein homolog 3

1

9

High-throughput

0.479

High

926346

SF3B2
Splicing factor 3B subunit 2

1

2

Small-scale

0.479

High

926349

SNW1
SNW domain-containing protein 1

1

5

High-throughput

0.479

High

926353

KLF9
Krueppel-like factor 9

1

7

High-throughput

0.479

High

926359

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

926368

PAXI1
PAX-interacting protein 1

1

13

Small-scale

0.479

High

926370

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

926377

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

926381

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

926383

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

926387

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

926393

ARK2N
Protein ARK2N

1

1

Small-scale

0.479

High

926400

CTIP
DNA endonuclease RBBP8

1

1

Small-scale

0.479

High

926405

KLF16
Krueppel-like factor 16

1

6

High-throughput

0.479

High

926407

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

17

High-throughput

0.479

High

926411

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

926414

ECT2
Protein ECT2

1

8

Small-scale

0.479

High

926417

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

6

High-throughput

0.479

High

926421

MIOS
GATOR2 complex protein MIOS

1

4

High-throughput

0.479

High

926423

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

926426

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

9

High-throughput

0.479

High

926428

KLF15
Krueppel-like factor 15

1

8

High-throughput

0.479

High

926429

NUP50
Nuclear pore complex protein Nup50

1

4

High-throughput

0.479

High

926434

LHX6
LIM/homeobox protein Lhx6

1

3

High-throughput

0.479

High

926435

PHF8
Histone lysine demethylase PHF8

1

3

Small-scale

0.479

High

926438

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

926440

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

926441

KLF12
Krueppel-like factor 12

1

9

High-throughput

0.479

High

926397

MCRS1
Microspherule protein 1

1

0

Small-scale

0.460

High

70860

CENPX
Centromere protein X

1

0

Small-scale

0.458

High

185176

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.458

High

303013

PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

341921

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

697053

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

926327

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

926339

FP100
Fanconi anemia core complex-associated protein 100

1

0

Small-scale

0.458

High

926345

XRCC4
DNA repair protein XRCC4

1

0

Small-scale

0.458

High

926366

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

926392

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

926394

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

926408

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

926413

EXO5
Exonuclease V

1

0

Small-scale

0.458

High

926422

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

926427

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

290496

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.445

High

769954

RFC1
Replication factor C subunit 1

1

5

Small-scale

0.445

High

926314

RL26
Large ribosomal subunit protein uL24

1

5

High-throughput

0.445

High

926335

RL18A
Large ribosomal subunit protein eL20

1

2

High-throughput

0.445

High

926358

MO4L2
Mortality factor 4-like protein 2

1

2

High-throughput

0.445

High

926373

SHLD2
Shieldin complex subunit 2

1

2

Small-scale

0.445

High

926424

GRHL1
Grainyhead-like protein 1 homolog

1

6

High-throughput

0.445

High

926433

RL26L
Ribosomal protein uL24-like

1

5

High-throughput

0.437

High

926365

INT3
Integrator complex subunit 3

1

0

Small-scale

0.426

High

87389

OSCRI
SCRIB overlapping open reading frame protein

1

2

High-throughput

0.407

High

108005

SO1B7
Putative solute carrier organic anion transporter family member 1B7

1

0

High-throughput

0.232

Low

926403

PHAF1
Phagosome assembly factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025