HitPredict

Interactor 1: TYDP2 (O95551)
Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase)
Gene: TDP2

Interactor 2: SUMO3 (P55854)
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Gene: SUMO3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	35914814, 16524884
Identification Methods	two hybrid, pull down, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Exo_endo_phos~Rad60-SLD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016605 - PML body
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 362 Hs			1 103
+	Hs
		316318 TYDP2_HUMAN (1-362): 1.96e-137: 397: 100.00		SUMO2_HUMAN (1-93): 4.15e-41: 132: 96.81
+	Hs
		316320 TYDP2_HUMAN (1-362): 1.96e-137: 397: 100.00		SUMO1_HUMAN (1-92): 2.47e-36: 120: 48.45