Protein: PALS1
Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)

Gene: PALS1
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q8N3R9

Gene Ontology (top 5):
GO:0002011 - morphogenesis of an epithelial sheet
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

167711

LIN7A
Protein lin-7 homolog A

8

20

Small-scale

0.973

High

1325321

LIN7C
Protein lin-7 homolog C

7

20

High-throughput

0.964

High

1325295

INADL
InaD-like protein

5

19

Small-scale

0.931

High

1325312

LIN7B
Protein lin-7 homolog B

5

20

High-throughput

0.924

High

299772

MPDZ
Multiple PDZ domain protein

3

17

High-throughput

0.871

High

1325292

PALS1
Protein PALS1

3

17

Small-scale

0.821

High

1325302

SH3K1
SH3 domain-containing kinase-binding protein 1

2

8

High-throughput

0.811

High

1325323

SNTG2
Gamma-2-syntrophin

2

20

High-throughput

0.783

High

1197013

AMOT
Angiomotin

8

14

Small-scale

0.752

High

862291

YAP1
Transcriptional coactivator YAP1

8

20

Small-scale

0.752

High

1325304

MPP4
MAGUK p55 subfamily member 4

1

18

Small-scale

0.700

High

1325331

AMOL2
Angiomotin-like protein 2

4

12

Small-scale

0.699

High

1257273

STXB4
Syntaxin-binding protein 4

1

20

High-throughput

0.691

High

1325296

SOCS4
Suppressor of cytokine signaling 4

2

16

High-throughput

0.686

High

1314080

AMOL1
Angiomotin-like protein 1

3

14

High-throughput

0.675

High

1010995

CRUM1
Protein crumbs homolog 1

3

10

Small-scale

0.644

High

1325309

CRUM3
Protein crumbs homolog 3

2

4

Small-scale

0.629

High

171733

GAK
Cyclin-G-associated kinase

2

6

High-throughput

0.628

High

1252066

RN19B
E3 ubiquitin-protein ligase RNF19B

2

11

High-throughput

0.628

High

1325320

HOME3
Homer protein homolog 3

2

6

High-throughput

0.628

High

1325329

RP3A
Rabphilin-3A

2

2

High-throughput

0.628

High

1325333

PCDC2
Protocadherin alpha-C2

2

2

High-throughput

0.628

High

889306

NUMB
Protein numb homolog

1

8

High-throughput

0.621

High

374757

RASH
GTPase HRas

1

17

High-throughput

0.618

High

375714

RASK
GTPase KRas

1

20

High-throughput

0.618

High

710361

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

962263

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

978159

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1145009

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.618

High

1254622

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.618

High

1325315

PAR6A
Partitioning defective 6 homolog alpha

1

18

Small-scale

0.618

High

1311630

KIBRA
Protein KIBRA

2

17

Small-scale

0.611

High

1090782

TRAF2
TNF receptor-associated factor 2

2

6

High-throughput

0.606

High

1244619

GASP3
G protein-coupled receptor associated sorting protein 3

2

1

High-throughput

0.606

High

1325327

DLGP4
Disks large-associated protein 4

2

20

High-throughput

0.606

High

955370

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.590

High

351490

FTCD
Formimidoyltransferase-cyclodeaminase

2

0

High-throughput

0.580

High

318090

PKHG5
Pleckstrin homology domain-containing family G member 5

1

13

High-throughput

0.575

High

1115557

ASPP2
Apoptosis-stimulating of p53 protein 2

1

3

High-throughput

0.575

High

1245251

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

1

13

Small-scale

0.575

High

1325307

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.575

High

1325317

PDLI7
PDZ and LIM domain protein 7

1

4

High-throughput

0.575

High

767259

MERL
Merlin

2

20

Small-scale

0.552

High

861680

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.536

High

1052064

CALD1
Caldesmon

1

7

High-throughput

0.536

High

1254016

RIPR1
Rho family-interacting cell polarization regulator 1

1

4

High-throughput

0.536

High

1310221

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

1325330

E41L3
Band 4.1-like protein 3

1

17

High-throughput

0.536

High

1325336

NEMO
NF-kappa-B essential modulator

1

4

High-throughput

0.536

High

1325313

E41L5
Band 4.1-like protein 5

1

20

Small-scale

0.529

High

1325318

LATS2
Serine/threonine-protein kinase LATS2

1

7

High-throughput

0.515

High

442398

GELS
Gelsolin

1

1

High-throughput

0.515

High

650293

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.515

High

843758

HD
Huntingtin

1

3

High-throughput

0.515

High

1325325

UBQL1
Ubiquilin-1

1

3

High-throughput

0.515

High

1315094

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.513

High

1325305

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

389854

TTHY
Transthyretin

1

0

High-throughput

0.493

High

927057

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

333900

SIX3
Homeobox protein SIX3

1

2

High-throughput

0.489

High

1123040

FHL2
Four and a half LIM domains protein 2

1

5

High-throughput

0.489

High

1260651

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

4

High-throughput

0.489

High

516073

SRG2B
SLIT-ROBO Rho GTPase-activating protein 2B

1

4

High-throughput

0.481

High

132160

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

10

High-throughput

0.479

High

349157

LATS1
Serine/threonine-protein kinase LATS1

1

3

High-throughput

0.479

High

372562

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

468588

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

675080

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

High-throughput

0.479

High

929996

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

1140552

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

1197641

MIDN
Midnolin

1

3

High-throughput

0.479

High

1227056

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1229246

RHG17
Rho GTPase-activating protein 17

1

5

Small-scale

0.479

High

1256516

CE128
Centrosomal protein of 128 kDa

1

7

High-throughput

0.479

High

1325310

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1325311

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

10

Small-scale

0.479

High

1325314

E41LA
Band 4.1-like protein 4A

1

20

High-throughput

0.479

High

1325326

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

1

High-throughput

0.479

High

46620

A0A286YEY3
SLIT-ROBO Rho GTPase activating protein 2B

1

4

High-throughput

0.470

High

315772

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

467545

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

657634

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

867269

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1135736

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1156770

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1325297

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1325324

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

414197

P53
Cellular tumor antigen p53

1

1

Small-scale

0.445

High

744463

SSR3
Somatostatin receptor type 3

1

14

Small-scale

0.445

High

854688

RAGP1
Ran GTPase-activating protein 1

1

3

High-throughput

0.445

High

876491

K2C6C
Keratin, type II cytoskeletal 6C

1

2

High-throughput

0.445

High

1063428

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.445

High

1085897

TWF1
Twinfilin-1

1

2

High-throughput

0.445

High

1234861

PKHA7
Pleckstrin homology domain-containing family A member 7

1

19

High-throughput

0.445

High

1280198

MILR1
Allergin-1

1

4

High-throughput

0.445

High

1295193

HOME1
Homer protein homolog 1

1

6

High-throughput

0.445

High

1325293

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.445

High

1325298

TSC1
Hamartin

1

6

High-throughput

0.445

High

1325299

HMHA1
Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1

1

4

High-throughput

0.445

High

1325301

CSN5
COP9 signalosome complex subunit 5

1

2

Small-scale

0.445

High

1325303

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

3

High-throughput

0.445

High

1325306

FRMD6
FERM domain-containing protein 6

1

20

High-throughput

0.445

High

1325319

HOME2
Homer protein homolog 2

1

6

High-throughput

0.445

High

1325300

ESR2
Estrogen receptor beta

1

6

High-throughput

0.437

High

1325308

TEAD3
Transcriptional enhancer factor TEF-5

1

1

High-throughput

0.437

High

1325316

ANLN
Anillin

1

1

High-throughput

0.437

High

1325322

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

High-throughput

0.437

High

1325328

NINL
Ninein-like protein

1

3

High-throughput

0.437

High

1325334

MAFB
Transcription factor MafB

1

3

High-throughput

0.437

High

165060

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.426

High

502055

H2AZ
Histone H2A.Z

1

0

High-throughput

0.426

High

516556

CALM3
Calmodulin-3

1

0

High-throughput

0.426

High

1256782

LHPL2
LHFPL tetraspan subfamily member 2 protein

1

0

High-throughput

0.426

High

1325335

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.426

High

488249

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.328

High

1325294

TNIP2
TNFAIP3-interacting protein 2

2

0

High-throughput

0.318

High

1289913

F124A
Protein FAM124A

2

0

High-throughput

0.313

High

66799

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.279

Low

301557

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1325332

ZN451
E3 SUMO-protein ligase ZNF451

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025