HitPredict

Interactor 1: PCNT (O95613)
Pericentrin (Kendrin) (Pericentrin-B)
Gene: PCNT

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	35914814
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005874 - microtubule GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3336 Hs			1 7388
+	Hs
		1061289 NUMA1_HUMAN (43-1227): 1.53e-33: 145: 10.92		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		110636 MYH9_HUMAN (2690-3313): 1.18e-18: 96.7: 9.89		H3BPE1_HUMAN (66-7004): 0: 1955: 82.41
+	Hs
		317252 PCNT_HUMAN (1-3336): 0: 718: 100.00		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		317303 PCNT_HUMAN (1-3336): 0: 718: 100.00		SYNE1_HUMAN (343-1742): 3.05e-13: 80.2: 8.97
+	Hs
		317231 PCNT_HUMAN (1-3336): 0: 718: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		164543 PCNT_HUMAN (1-3336): 0: 718: 100.00		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		317230 PCNT_HUMAN (1-3336): 0: 718: 100.00		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		317220 PCNT_HUMAN (1-3336): 0: 718: 100.00		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		317246 PCNT_HUMAN (1-3336): 0: 718: 100.00		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Mm
		513821 PLEC_MOUSE (2-1335): 1.57e-39: 165: 10.63		DMD_MOUSE (69-1516): 9.33e-77: 290: 18.75
+	Hs
		885304 CP250_HUMAN (1630-3336): 3.41e-53: 210: 10.43		EPIPL_HUMAN (1538-2789): 1.49e-35: 154: 13.15
+	Hs
		969584 CENPE_HUMAN (1328-3305): 2.89e-65: 250: 10.28		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Mm
		93578 PLEC_MOUSE (2-1335): 1.57e-39: 165: 10.63		DESP_MOUSE (2737-3805): 1.11e-27: 127: 8.89
+	Hs
		974137 CP250_HUMAN (1630-3336): 3.41e-53: 210: 10.43		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Dm
		962674 LVA_DROME (1967-3211): 1.36e-32: 142: 10.43		SPTCB_DROME (411-1266): 2.51e-17: 93.6: 10.77
+	Hs
		166696 CE290_HUMAN (1764-3201): 5.48e-34: 147: 10.55		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		522612 MYH7_HUMAN (2483-3316): 1.1e-33: 146: 12.07		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		1034577 GOGA4_HUMAN (2170-3252): 2.83e-32: 141: 10.17		GOGB1_HUMAN (6684-7219): 2.29e-10: 70.5: 9.23
+	Hs
		1059212 GOGB1_HUMAN (2204-3322): 8.52e-25: 117: 9.50		GOGB1_HUMAN (6684-7219): 2.29e-10: 70.5: 9.23
+	Hs
		164575 MYH9_HUMAN (2690-3313): 1.18e-18: 96.7: 9.89		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59