HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	26474068, 30279242, 31582797, 22261722
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006974 - DNA damage response
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 616
+	Hs
		319880 HERC2_HUMAN (1-4834): 0: 6206: 100.00		RADX_HUMAN (27-384): 6.8e-66: 233: 16.24
+	Hs
		651966 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650616 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		651570 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		651304 HERC1_HUMAN (2867-3016): 8.76e-11: 71.4: 12.34		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		652547 HERC5_HUMAN (424-597): 6.72e-11: 71.2: 26.56		RFA1_HUMAN (1-616): 0: 781: 100.00