HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: COPB2 (P35606)
Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102)
Gene: COPB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	25476789, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 906
+	Hs
		319769 HERC2_HUMAN (1-4834): 0: 6206: 100.00		COPA_HUMAN (7-900): 1.24e-158: 498: 22.74
+	Hs
		725523 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		COPB2_HUMAN (1-906): 0: 736: 100.00
+	Hs
		725568 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		COPB2_HUMAN (1-906): 0: 736: 100.00
+	Hs
		725481 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		COPB2_HUMAN (1-906): 0: 736: 100.00
+	Sc
		765291 RSP5_YEAST (4316-4794): 6.73e-160: 520: 18.52		COPB2_YEAST (3-841): 1.41e-165: 507: 43.87
+	Sc
		765342 RSP5_YEAST (4316-4794): 6.73e-160: 520: 18.52		COPA_YEAST (5-433): 5.89e-67: 245: 14.18
+	Hs
		125310 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		WDR5_HUMAN (553-670): 9.92e-20: 93.4: 8.94