HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29511261, 36089195
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 136
+	Hs
		319857 HERC2_HUMAN (1-4834): 0: 6206: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		319881 HERC2_HUMAN (1-4834): 0: 6206: 100.00		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		808088 NEDD4_HUMAN (4323-4795): 7.15e-167: 557: 20.29		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		125375 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		952638 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Sc
		765356 RSP5_YEAST (4316-4794): 6.73e-160: 520: 18.52		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Hs
		1065039 HERC3_HUMAN (310-574): 2.63e-42: 173: 16.94		H37_HUMAN (1-136): 4.54e-57: 175: 94.12