Protein: PPM1B
Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)

Gene: PPM1B
Organism: Homo sapiens
Interactions: 215
UniProt ID: O75688

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

290877

PPM1A
Protein phosphatase 1A

3

2

High-throughput

0.861

High

167776

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

17

Small-scale

0.770

High

290996

TBK1
Serine/threonine-protein kinase TBK1

2

20

Small-scale

0.754

High

290932

KPCD1
Serine/threonine-protein kinase D1

2

8

High-throughput

0.737

High

290859

CDK2
Cyclin-dependent kinase 2

1

4

Small-scale

0.710

High

290916

CDK6
Cyclin-dependent kinase 6

1

7

Small-scale

0.710

High

136036

PLK4
Serine/threonine-protein kinase PLK4

1

18

High-throughput

0.691

High

290897

NEK4
Serine/threonine-protein kinase Nek4

1

15

High-throughput

0.691

High

290930

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

2

High-throughput

0.667

High

177749

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.665

High

290936

CERKL
Ceramide kinase-like protein

3

1

High-throughput

0.662

High

290850

PVR
Poliovirus receptor

3

0

High-throughput

0.634

High

290949

HTR5A
HEAT repeat-containing protein 5A

3

0

High-throughput

0.634

High

290979

PAXX
Protein PAXX

3

0

High-throughput

0.634

High

290980

THUM3
tRNA

3

0

High-throughput

0.634

High

271645

HIP1R
Huntingtin-interacting protein 1-related protein

2

1

High-throughput

0.628

High

290838

PMGE
Bisphosphoglycerate mutase

2

1

High-throughput

0.628

High

290820

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.618

High

290863

MARK3
MAP/microtubule affinity-regulating kinase 3

1

6

Small-scale

0.618

High

290896

PPM1F
Protein phosphatase 1F

1

3

High-throughput

0.618

High

290966

AURKB
Aurora kinase B

1

13

High-throughput

0.618

High

290855

VDAC1
Non-selective voltage-gated ion channel VDAC1

2

1

High-throughput

0.611

High

290960

MINY2
Ubiquitin carboxyl-terminal hydrolase MINDY-2

3

1

High-throughput

0.609

High

290918

MLRA
Myosin regulatory light chain 2, atrial isoform

2

3

High-throughput

0.606

High

290999

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

2

High-throughput

0.606

High

290900

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.601

High

213740

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

7

Small-scale

0.597

High

290856

ERBB3
Receptor tyrosine-protein kinase erbB-3

3

14

High-throughput

0.596

High

290833

ISG15
Ubiquitin-like protein ISG15

2

4

Small-scale

0.588

High

290834

K1C18
Keratin, type I cytoskeletal 18

2

0

High-throughput

0.576

High

290970

SNX27
Sorting nexin-27

2

0

High-throughput

0.576

High

290845

FGFR1
Fibroblast growth factor receptor 1

2

8

High-throughput

0.571

High

290879

PPARG
Peroxisome proliferator-activated receptor gamma

1

2

Small-scale

0.561

High

290951

RBM45
RNA-binding protein 45

1

1

High-throughput

0.554

High

290993

KS6B2
Ribosomal protein S6 kinase beta-2

1

1

Small-scale

0.553

High

290981

IL25
Interleukin-25

2

1

High-throughput

0.549

High

290853

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

290865

ELK4
ETS domain-containing protein Elk-4

2

0

High-throughput

0.547

High

290869

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.547

High

290933

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

0

High-throughput

0.547

High

290823

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.541

High

290872

RYK
Tyrosine-protein kinase RYK

1

6

High-throughput

0.541

High

290878

VGFR2
Vascular endothelial growth factor receptor 2

1

6

High-throughput

0.541

High

290924

PTK7
Inactive tyrosine-protein kinase 7

1

5

High-throughput

0.541

High

290934

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

10

High-throughput

0.541

High

290944

LMTK1
Serine/threonine-protein kinase LMTK1

1

15

High-throughput

0.541

High

277483

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.536

High

290812

SEGN
Secretagogin

1

1

High-throughput

0.536

High

290822

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

290831

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.536

High

290843

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

290848

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.536

High

290871

ARRB2
Beta-arrestin-2

1

3

High-throughput

0.536

High

290875

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.536

High

290876

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.536

High

290880

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

1

High-throughput

0.536

High

290894

ARRB1
Beta-arrestin-1

1

3

High-throughput

0.536

High

290912

ACTS
Actin, alpha skeletal muscle

1

2

High-throughput

0.536

High

290917

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.536

High

290928

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.536

High

290950

H2A2B
Histone H2A type 2-B

1

2

High-throughput

0.536

High

290990

DPOE3
DNA polymerase epsilon subunit 3

1

1

High-throughput

0.536

High

290827

ANXA1
Annexin A1

1

1

High-throughput

0.515

High

290832

S10A8
Protein S100-A8

1

2

High-throughput

0.515

High

290835

GELS
Gelsolin

1

2

High-throughput

0.515

High

290836

ANXA2
Annexin A2

1

1

High-throughput

0.515

High

290925

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.515

High

291007

NEMO
NF-kappa-B essential modulator

1

2

Small-scale

0.515

High

290946

NEK10
Serine/threonine-protein kinase Nek10

1

18

High-throughput

0.514

High

290840

VIME
Vimentin

1

0

High-throughput

0.513

High

290899

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.513

High

290922

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

290942

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.513

High

290962

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.513

High

290963

NGN1
Neurogenin-1

1

0

High-throughput

0.513

High

290973

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

290982

PRD13
PR domain zinc finger protein 13

1

0

High-throughput

0.513

High

290984

ROP1A
Ropporin-1A

1

0

High-throughput

0.513

High

290987

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

291005

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.513

High

290898

VAV2
Guanine nucleotide exchange factor VAV2

1

2

High-throughput

0.508

High

290919

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

15

High-throughput

0.494

High

290920

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

12

High-throughput

0.494

High

290817

GRP1
RAS guanyl-releasing protein 1

1

0

High-throughput

0.493

High

290883

TXLNA
Alpha-taxilin

1

0

High-throughput

0.493

High

290907

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.493

High

290854

S1PR1
Sphingosine 1-phosphate receptor 1

1

1

High-throughput

0.489

High

290866

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

290956

PGAM4
Probable phosphoglycerate mutase 4

1

1

High-throughput

0.489

High

290968

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.489

High

290972

RB40C
Ras-related protein Rab-40C

1

1

High-throughput

0.489

High

290976

RSLBB
Ras-like protein family member 11B

1

1

High-throughput

0.489

High

290986

LPAR2
Lysophosphatidic acid receptor 2

1

1

High-throughput

0.489

High

290914

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

0

Small-scale

0.480

High

137886

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

172333

XPO1
Exportin-1

1

1

High-throughput

0.479

High

240301

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

257293

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

290819

HERC2
E3 ubiquitin-protein ligase HERC2

1

2

High-throughput

0.479

High

290826

ESR1
Estrogen receptor

1

2

High-throughput

0.479

High

290839

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

290849

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.479

High

290851

CXA1
Gap junction alpha-1 protein

1

1

Small-scale

0.479

High

290857

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.479

High

290864

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

290882

CAPG
Macrophage-capping protein

1

2

Small-scale

0.479

High

290884

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.479

High

290887

MAGA3
Melanoma-associated antigen 3

1

2

Small-scale

0.479

High

290888

MAGA6
Melanoma-associated antigen 6

1

2

High-throughput

0.479

High

290889

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

290891

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.479

High

290901

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.479

High

290904

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

290906

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

290909

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.479

High

290913

H31
Histone H3.1

1

1

High-throughput

0.479

High

290937

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

290940

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.479

High

290953

TRI59
Tripartite motif-containing protein 59

1

1

Small-scale

0.479

High

290954

FANCM
Fanconi anemia group M protein

1

1

High-throughput

0.479

High

290964

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

1

High-throughput

0.479

High

290965

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.479

High

290974

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.479

High

290975

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

290988

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

290992

UBP35
Ubiquitin carboxyl-terminal hydrolase 35

1

1

Small-scale

0.479

High

290995

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

291000

FBXL4
F-box/LRR-repeat protein 4

1

1

Small-scale

0.479

High

290841

VILI
Villin-1

1

2

High-throughput

0.470

High

131094

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.458

High

247567

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

259223

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

275861

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

0

Small-scale

0.458

High

290813

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

290814

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

290821

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

290825

FOS
Protein c-Fos

1

0

High-throughput

0.458

High

290830

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

290842

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

290846

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

290847

SKI
Ski oncogene

1

0

Small-scale

0.458

High

290860

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

290862

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.458

High

290867

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

290870

GCH1
GTP cyclohydrolase 1

1

0

Small-scale

0.458

High

290873

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

290874

K1C9
Keratin, type I cytoskeletal 9

1

0

High-throughput

0.458

High

290881

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

290885

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

290886

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

290890

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

290892

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.458

High

290893

FNTB
Protein farnesyltransferase subunit beta

1

0

High-throughput

0.458

High

290895

SYAC
Alanine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

290903

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

290905

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

290910

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

290915

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.458

High

290921

TLE4
Transducin-like enhancer protein 4

1

0

Small-scale

0.458

High

290926

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

High-throughput

0.458

High

290931

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.458

High

290935

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

290941

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

290948

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

290957

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

290969

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

290978

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.458

High

290983

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

290985

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

290989

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

290991

KIF15
Kinesin-like protein KIF15

1

0

High-throughput

0.458

High

290997

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

291001

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

291002

PRP19
Pre-mRNA-processing factor 19

1

0

High-throughput

0.458

High

291004

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

47478

RPSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.445

High

142252

PEX7
Peroxisomal targeting signal 2 receptor

1

2

High-throughput

0.445

High

290828

PRIO
Major prion protein

1

1

High-throughput

0.445

High

290844

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

290852

CAP7
Azurocidin

1

3

High-throughput

0.445

High

290861

DNJB2
DnaJ homolog subfamily B member 2

1

1

High-throughput

0.445

High

290908

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.445

High

290939

H37
Histone H3-7

1

1

High-throughput

0.445

High

291003

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

104966

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

290837

TRY1
Serine protease 1

1

1

High-throughput

0.437

High

290945

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

290994

KLK11
Kallikrein-11

1

1

High-throughput

0.437

High

290824

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

290858

CRHBP
Corticotropin-releasing factor-binding protein

1

0

High-throughput

0.426

High

290911

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.426

High

290923

IFT88
Intraflagellar transport protein 88 homolog

1

0

High-throughput

0.426

High

290961

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.426

High

290816

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

290927

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

290938

S1A7B
Protein S100-A7-like 2

1

3

High-throughput

0.407

High

290977

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

1

High-throughput

0.407

High

290955

CA087
Uncharacterized protein C1orf87

2

0

High-throughput

0.328

High

290998

FEZ2
Fasciculation and elongation protein zeta-2

2

0

High-throughput

0.328

High

290929

LRC32
Transforming growth factor beta activator LRRC32

2

0

High-throughput

0.313

High

290868

ECHM
Enoyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.282

High

290818

APOM
Apolipoprotein M

1

0

High-throughput

0.279

Low

290947

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

290967

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.279

Low

49362

A0N4V7
HCG2039797

1

0

High-throughput

0.249

Low

290815

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.249

Low

290829

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.249

Low

290902

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.249

Low

290958

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

0

Small-scale

0.249

Low

290959

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

290971

ZDH15
Palmitoyltransferase ZDHHC15

1

0

Small-scale

0.249

Low

291006

INSI2
Insulin-induced gene 2 protein

1

0

High-throughput

0.249

Low

87284

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

290943

CLC4G
C-type lectin domain family 4 member G

1

0

Small-scale

0.232

Low

290952

DAA19
Dynein axonemal assembly factor 19

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025