HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29511261
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 494
+	Hs
		319701 HERC2_HUMAN (1-4834): 0: 6206: 100.00		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		319819 HERC2_HUMAN (1-4834): 0: 6206: 100.00		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Hs
		125406 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		992925 WWP1_HUMAN (4323-4794): 3.33e-165: 539: 20.88		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		125426 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		125425 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		1028813 WWP1_HUMAN (4323-4794): 3.33e-165: 539: 20.88		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Dm
		1373179 SUDX_DROME (4313-4791): 1.35e-162: 533: 19.64		Q9VRM6_DROME (157-484): 6.13e-44: 168: 26.02
+	Hs
		992947 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		516643 ITCH_HUMAN (4308-4794): 3.88e-172: 559: 21.37		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		125122 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		992830 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		125430 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Hs
		1028715 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		1029150 HERC5_HUMAN (424-597): 6.72e-11: 71.2: 26.56		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		1308801 HERC5_HUMAN (424-597): 6.72e-11: 71.2: 26.56		RBM4B_HUMAN (3-104): 4.68e-11: 66.1: 23.08