HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: BICD2 (Q8TD16)
Protein bicaudal D homolog 2 (Bic-D 2)
Gene: BICD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25476789, 28718761, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 824
+	Hs
		319969 HERC2_HUMAN (1-4834): 0: 6206: 100.00		BICD1_HUMAN (11-813): 1.24e-54: 206: 61.22
+	Hs
		319994 HERC2_HUMAN (1-4834): 0: 6206: 100.00		CP250_HUMAN (90-822): 4.68e-22: 104: 12.35
+	Hs
		319864 HERC2_HUMAN (1-4834): 0: 6206: 100.00		GRDN_HUMAN (153-824): 4.09e-18: 92.1: 10.43
+	Mm
		1118137 HERC2_MOUSE (1-4834): 0: 6208: 95.51		MYH10_MOUSE (530-823): 4.44e-10: 65.9: 11.11
+	Hs
		1113845 WWP1_HUMAN (4323-4794): 3.33e-165: 539: 20.88		GRDN_HUMAN (153-824): 4.09e-18: 92.1: 10.43
+	Hs
		1113852 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		GRDN_HUMAN (153-824): 4.09e-18: 92.1: 10.43
+	Hs
		1336100 SMUF1_HUMAN (4321-4794): 2.56e-156: 507: 20.58		DAPLE_HUMAN (7-536): 5.59e-11: 68.8: 20.00
+	Hs
		1192196 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		CP250_HUMAN (90-822): 4.68e-22: 104: 12.35
+	Hs
		724896 HUWE1_HUMAN (4365-4788): 5.93e-118: 425: 24.00		MYH9_HUMAN (530-824): 4.55e-10: 65.9: 12.75
+	Hs
		148866 HERC1_HUMAN (2867-3016): 8.76e-11: 71.4: 12.34		CTRO_HUMAN (17-823): 1.27e-10: 67.6: 15.51