HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: S23IP (Q9Y6Y8)
SEC23-interacting protein (p125)
Gene: SEC23IP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29511261, 22261722
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006886 - intracellular protein transport
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 1000
+	Mm
		102638 HERC2_MOUSE (1-4834): 0: 6208: 95.51		G3X928_MOUSE (1-1000): 0: 1040: 86.03
+	Mm
		1118142 HERC2_MOUSE (1-4834): 0: 6208: 95.51		S23IP_MOUSE (1-1000): 0: 1039: 85.73
+	Hs
		225324 HERC2_HUMAN (1-4834): 0: 6206: 100.00		MED14_HUMAN (24-217): 5.47e-10: 65.8: 15.98
+	Dm
		1370265 HERC2_DROME (14-4824): 0: 4329: 42.30		Q9VLS7_DROME (735-996): 7.37e-50: 195: 40.71
+	Hs
		1327945 WWP1_HUMAN (4323-4794): 3.33e-165: 539: 20.88		S23IP_HUMAN (1-1000): 0: 1085: 100.00
+	Hs
		123777 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		SPT5H_HUMAN (25-328): 9.63e-34: 142: 20.13
+	Dm
		1370333 Q9VXR3_DROME (4369-4788): 8.87e-117: 422: 25.64		Q9VLS7_DROME (735-996): 7.37e-50: 195: 40.71
+	Hs
		125274 WWP2_HUMAN (4317-4794): 2.23e-166: 541: 19.22		SC24C_HUMAN (33-278): 2.74e-09: 63.5: 17.03