HitPredict

Interactor 1: GGPPS (O95749)
Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
Gene: GGPS1

Interactor 2: GGPPS (O95749)
Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
Gene: GGPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.893

The method score is based on:

Property Details
Experiments 25416956, 32296183, 31515488, unassigned1304
Identification Methods two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains polyprenyl_synt~polyprenyl_synt
Common GO terms GO:0004161 - dimethylallyltranstransferase activity
GO:0004311 - farnesyltranstransferase activity
GO:0004337 - geranyltranstransferase activity
GO:0004659 - prenyltransferase activity
GO:0005654 - nucleoplasm
and 14 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 300
Hs

1 300
+ At
+ Ec
+ Hs
+ Hs
+ Sp
+ Hs
+ Sp
+ Sp
+ Sc
+ Hp
+ Sp
+ Ec

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024