Protein: EGLN1
Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)

Gene: EGLN1
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q9GZT9

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004857 - enzyme inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1161387

HIF1A
Hypoxia-inducible factor 1-alpha

29

14

Small-scale

0.991

High

1407414

EPAS1
Endothelial PAS domain-containing protein 1

7

14

Small-scale

0.959

High

1125645

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

10

5

Small-scale

0.756

High

1428874

EGLN3
Prolyl hydroxylase EGLN3

2

4

Small-scale

0.754

High

468780

HS90B
Heat shock protein HSP 90-beta

4

1

Small-scale

0.692

High

1144154

TEBP
Prostaglandin E synthase 3

5

0

Small-scale

0.684

High

1411836

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

1

High-throughput

0.667

High

461910

HS90A
Heat shock protein HSP 90-alpha

2

1

Small-scale

0.624

High

822855

VHL
von Hippel-Lindau disease tumor suppressor

2

1

Small-scale

0.624

High

270271

MTG16
Protein CBFA2T3

1

1

Small-scale

0.618

High

1055272

MTG8
Protein CBFA2T1

1

2

Small-scale

0.618

High

1428872

EGLN1
Egl nine homolog 1

1

4

Small-scale

0.618

High

1106065

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

5

Small-scale

0.611

High

1428882

ING4
Inhibitor of growth protein 4

2

0

Small-scale

0.605

High

1358008

EFMT1
EEF1A lysine methyltransferase 1

2

0

High-throughput

0.602

High

211595

SIAH2
E3 ubiquitin-protein ligase SIAH2

2

3

Small-scale

0.584

High

693362

ARNT
Aryl hydrocarbon receptor nuclear translocator

2

14

Small-scale

0.584

High

1114245

CUL3
Cullin-3

2

1

Small-scale

0.584

High

1347772

OSR1
Protein odd-skipped-related 1

2

1

Small-scale

0.584

High

1428879

LIMD1
LIM domain-containing protein 1

2

11

Small-scale

0.584

High

557461

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.578

High

1428875

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

2

0

High-throughput

0.576

High

848938

MAGAB
Melanoma-associated antigen 11

1

6

Small-scale

0.573

High

1384258

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

Small-scale

0.573

High

1105558

OS9
Protein OS-9

2

1

Small-scale

0.565

High

1428884

ZN281
Zinc finger protein 281

1

1

High-throughput

0.541

High

1408435

CITE1
Cbp/p300-interacting transactivator 1

1

1

High-throughput

0.536

High

998787

H31
Histone H3.1

1

0

Small-scale

0.527

High

375926

RASK
GTPase KRas

1

0

High-throughput

0.518

High

573242

KPYM
Pyruvate kinase PKM

1

1

Small-scale

0.515

High

630034

BTF3
Transcription factor BTF3

1

0

High-throughput

0.513

High

1103794

PLD1
Phospholipase D1

1

1

Small-scale

0.512

High

140428

SDCB1
Syntenin-1

1

3

Small-scale

0.501

High

159841

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

High-throughput

0.479

High

207976

TET3
Methylcytosine dioxygenase TET3

1

3

Small-scale

0.479

High

221184

SPY2
Protein sprouty homolog 2

1

2

Small-scale

0.479

High

227663

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

260428

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

294299

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

322761

RHBT3
Rho-related BTB domain-containing protein 3

1

6

Small-scale

0.479

High

346301

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

363830

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

411041

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.479

High

440200

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

465639

IGF1R
Insulin-like growth factor 1 receptor

1

3

High-throughput

0.479

High

582949

EZRI
Ezrin

1

1

High-throughput

0.479

High

621739

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

667439

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.479

High

728424

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

728617

AKT2
RAC-beta serine/threonine-protein kinase

1

2

Small-scale

0.479

High

777761

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.479

High

848717

MAGA9
Melanoma-associated antigen 9

1

6

Small-scale

0.479

High

862432

YAP1
Transcriptional coactivator YAP1

1

1

Small-scale

0.479

High

997117

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.479

High

1038698

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

5

Small-scale

0.479

High

1117069

RUNX3
Runt-related transcription factor 3

1

1

Small-scale

0.479

High

1121520

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.479

High

1139833

SETB1
Histone-lysine N-methyltransferase SETDB1

1

2

Small-scale

0.479

High

1157059

NTRK3
NT-3 growth factor receptor

1

4

High-throughput

0.479

High

1236138

TET2
Methylcytosine dioxygenase TET2

1

3

Small-scale

0.479

High

1307355

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

1

High-throughput

0.479

High

1356643

IASPP
RelA-associated inhibitor

1

6

Small-scale

0.479

High

1366555

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1403777

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

1428873

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1428876

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

Small-scale

0.479

High

1428878

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1428880

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.479

High

326839

SPN1
Snurportin-1

1

0

High-throughput

0.458

High

828444

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.458

High

975229

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1009616

PHLD
Phosphatidylinositol-glycan-specific phospholipase D

1

0

Small-scale

0.458

High

1117144

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.458

High

1257252

RFPLB
Ret finger protein-like 4B

1

0

High-throughput

0.458

High

1289609

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1419285

TRI55
Tripartite motif-containing protein 55

1

0

High-throughput

0.458

High

1428877

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

430340

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

168899

PLD2
Phospholipase D2

1

1

Small-scale

0.437

High

648660

FGFR4
Fibroblast growth factor receptor 4

1

3

High-throughput

0.437

High

650401

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.437

High

699098

CALX
Calnexin

1

1

High-throughput

0.437

High

1251953

LMTK1
Serine/threonine-protein kinase LMTK1

1

5

High-throughput

0.437

High

1428881

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.437

High

1428883

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.407

High

716227

ERP29
Endoplasmic reticulum resident protein 29

1

0

High-throughput

0.269

Low

643060

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

1160443

TAZ
Tafazzin

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025