HitPredict

Interactor 1: HS74L (O95757)
Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)
Gene: HSPA4L

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ANAPC3~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 839 Hs			1 303
+	Hs
		213427 HS74L_HUMAN (1-839): 0: 1032: 100.00		SGTA_HUMAN (3-140): 2.4e-33: 126: 29.71
+	Hs
		714464 HSP74_HUMAN (1-839): 0: 931: 62.60		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Mm
		821833 HS74L_MOUSE (1-839): 0: 1014: 92.14		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22
+	Hs
		714148 HSP74_HUMAN (1-839): 0: 931: 62.60		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		213491 HSP74_HUMAN (1-839): 0: 931: 62.60		SGTA_HUMAN (3-140): 2.4e-33: 126: 29.71
+	Ce
		105586 HSP1_CAEEL (2-603): 0: 808: 28.78		G5ECY6_CAEEL (26-301): 5.16e-47: 160: 38.77
+	Dm
		1371973 Q9VUC1_DROME (1-837): 0: 855: 42.71		Q9VPN5_DROME (26-202): 1.32e-15: 78.6: 17.30
+	Ce
		183700 HSP1_CAEEL (2-603): 0: 808: 28.78		STIP1_CAEEL (26-124): 4.72e-10: 61.6: 36.36
+	Mm
		1337510 HYOU1_MOUSE (1-817): 2.59e-82: 286: 27.00		CHIP_MOUSE (1-303): 1.23e-67: 214: 97.37
+	Dm
		365423 HSP71_DROME (1-494): 1.54e-78: 268: 33.20		Q9XYW6_DROME (28-303): 2.4e-57: 187: 57.25
+	Dm
		947912 HSP70_DROME (1-494): 1.54e-78: 268: 33.20		Q9XYW6_DROME (28-303): 2.4e-57: 187: 57.25
+	Dm
		1213535 HSP72_DROME (1-494): 9.1e-78: 266: 33.00		Q9XYW6_DROME (28-303): 2.4e-57: 187: 57.25
+	Dm
		1365847 HSP74_DROME (1-494): 9.38e-78: 266: 33.00		Q9XYW6_DROME (28-303): 2.4e-57: 187: 57.25
+	Hs
		714095 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	At
		1338010 HS704_ARATH (563-697): 7.39e-28: 122: 19.12		CHIP_ARATH (17-300): 4.28e-49: 166: 32.17
+	Hs
		297027 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		TOM70_HUMAN (4-212): 8.69e-40: 148: 22.47
+	Hs
		503738 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		213468 HSP7C_HUMAN (563-695): 1.3e-27: 121: 17.91		SGTA_HUMAN (3-140): 2.4e-33: 126: 29.71
+	At
		1338008 HS704_ARATH (563-697): 7.39e-28: 122: 19.12		HSOP1_ARATH (32-275): 6.03e-19: 88.9: 16.47
+	Hs
		713982 HS71L_HUMAN (563-703): 9.9e-28: 121: 19.72		TOM34_HUMAN (26-117): 9.37e-11: 63.5: 35.87