Interactor 1: RIGI (O95786)
Antiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
Gene: RIGI

Interactor 2: ISG15 (P05161)
Ubiquitin-like protein ISG15 (Interferon-induced 15 kDa protein) (Interferon-induced 17 kDa protein) (IP17) (Ubiquitin cross-reactive protein) (hUCRP)
Gene: ISG15

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.839

The method score is based on:

Property Details
Experiments 16009940, 29288164, 24448099
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, unspecified method
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD_2~ubiquitin
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009615 - response to virus
GO:0031625 - ubiquitin protein ligase binding
GO:0032728 - positive regulation of interferon-beta production
and 2 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 925
Hs

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Last updated: 15 Jul 2024