HitPredict

Interactor 1: BAG3 (O95817)
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
Gene: BAG3

Interactor 2: Q96IS6 (Q96IS6)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)
Gene: HSPA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BAG~HSP70
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 575 Hs			1 587
+	Hs
		324256 BAG3_HUMAN (1-575): 0: 809: 100.00		HS71L_HUMAN (1-587): 0: 872: 81.26
+	Hs
		324195 BAG3_HUMAN (1-575): 0: 809: 100.00		HSP7C_HUMAN (1-587): 0: 868: 100.00
+	Hs
		324216 BAG3_HUMAN (1-575): 0: 809: 100.00		HSP76_HUMAN (1-587): 0: 865: 76.49
+	Hs
		324435 BAG3_HUMAN (1-575): 0: 809: 100.00		Q53FC7_HUMAN (1-587): 0: 860: 75.98
+	Hs
		324190 BAG3_HUMAN (1-575): 0: 809: 100.00		HS71A_HUMAN (1-587): 0: 851: 83.48
+	Hs
		324298 BAG3_HUMAN (1-575): 0: 809: 100.00		HSP72_HUMAN (1-587): 0: 844: 84.21
+	Mm
		926166 BAG3_MOUSE (1-575): 0: 762: 83.31		HSP7C_MOUSE (1-587): 0: 867: 99.83
+	Mm
		571868 BAG3_MOUSE (1-575): 0: 762: 83.31		HS71B_MOUSE (1-587): 0: 861: 82.96
+	Mm
		571864 BAG4_MOUSE (381-499): 1.39e-37: 146: 43.70		HS71B_MOUSE (1-587): 0: 861: 82.96
+	Hs
		314010 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		HS71L_HUMAN (1-587): 0: 872: 81.26
+	Hs
		313996 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		HSP7C_HUMAN (1-587): 0: 868: 100.00
+	Hs
		314001 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		HSP76_HUMAN (1-587): 0: 865: 76.49
+	Hs
		314060 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		Q53FC7_HUMAN (1-587): 0: 860: 75.98
+	Hs
		314025 BAG4_HUMAN (381-499): 3.45e-33: 134: 43.70		HSP72_HUMAN (1-587): 0: 844: 84.21
+	Hs
		714093 BAG5_HUMAN (418-498): 3.23e-17: 86.4: 41.98		HS71L_HUMAN (1-587): 0: 872: 81.26
+	Hs
		504937 BAG5_HUMAN (418-498): 3.23e-17: 86.4: 41.98		HSP7C_HUMAN (1-587): 0: 868: 100.00
+	Dm
		505107 Q9VU81_DROME (398-498): 1.2e-26: 116: 32.11		HSP7D_DROME (1-553): 0: 838: 85.35
+	Dm
		65601 A8JNS4_DROME (398-498): 1.33e-26: 116: 32.11		HSP7D_DROME (1-553): 0: 838: 85.35
+	Hs
		564206 BAG5_HUMAN (418-498): 3.23e-17: 86.4: 41.98		HSP76_HUMAN (1-587): 0: 865: 76.49
+	Hs
		871826 BAG5_HUMAN (418-498): 3.23e-17: 86.4: 41.98		HSP72_HUMAN (1-587): 0: 844: 84.21