HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0000165 - MAPK cascade GO:0005524 - ATP binding GO:0006468 - protein phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 822
+	Hs
		508100 MINK1_HUMAN (1-1239): 0: 1120: 59.29		FGFR1_HUMAN (1-822): 0: 861: 100.00
+	Hs
		508260 TNIK_HUMAN (1-1239): 0: 1101: 60.56		FGFR1_HUMAN (1-822): 0: 861: 100.00
+	Hs
		324739 M4K4_HUMAN (1-1239): 0: 1227: 100.00		FGFR4_HUMAN (29-808): 0: 664: 55.60
+	Hs
		324742 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHB2_HUMAN (4-819): 0: 640: 18.07
+	Hs
		324761 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA5_HUMAN (3-791): 0: 639: 19.15
+	Hs
		324809 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA7_HUMAN (3-783): 0: 629: 19.40
+	Hs
		324762 M4K4_HUMAN (1-1239): 0: 1227: 100.00		EPHA4_HUMAN (3-783): 0: 620: 19.44
+	Hs
		608181 TNIK_HUMAN (1-1239): 0: 1101: 60.56		FGFR4_HUMAN (29-808): 0: 664: 55.60
+	Hs
		872460 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EPHA5_HUMAN (3-791): 0: 639: 19.15
+	Hs
		1072547 MINK1_HUMAN (1-1239): 0: 1120: 59.29		EPHA7_HUMAN (3-783): 0: 629: 19.40
+	Hs
		665680 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHB2_HUMAN (4-819): 0: 640: 18.07
+	Hs
		872502 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHA5_HUMAN (3-791): 0: 639: 19.15
+	Hs
		1072625 TNIK_HUMAN (1-1239): 0: 1101: 60.56		EPHA7_HUMAN (3-783): 0: 629: 19.40
+	Hs
		324810 M4K4_HUMAN (1-1239): 0: 1227: 100.00		NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08
+	Hs
		324713 M4K4_HUMAN (1-1239): 0: 1227: 100.00		NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96
+	Mm
		546291 TNIK_MOUSE (1-1239): 0: 1120: 62.43		NTRK2_MOUSE (111-762): 1.43e-163: 497: 23.74
+	Hs
		1083868 MINK1_HUMAN (1-1239): 0: 1120: 59.29		NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70
+	Hs
		1081533 MINK1_HUMAN (1-1239): 0: 1120: 59.29		NTRK3_HUMAN (163-762): 3.3e-161: 491: 25.08
+	Mm
		956967 M4K4_MOUSE (1-1239): 0: 1142: 88.17		PTK7_MOUSE (162-433): 2.54e-17: 89: 16.36
+	Mm
		1206831 MINK1_MOUSE (1-1239): 0: 1124: 59.30		PTK7_MOUSE (162-433): 2.54e-17: 89: 16.36