Protein: NH2L1
NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]

Gene: NH2L1, SNU13
Organism: Homo sapiens
Interactions: 167
UniProt ID: P55769

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000492 - box C/D snoRNP assembly
GO:0001651 - dense fibrillar component
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

140829

NOP56
Nucleolar protein 56

6

9

Small-scale

0.935

High

209227

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

4

10

Small-scale

0.905

High

643743

FBRL
rRNA 2'-O-methyltransferase fibrillarin

4

2

High-throughput

0.887

High

938418

NUFP1
FMR1-interacting protein NUFIP1

4

1

Small-scale

0.882

High

215058

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

3

0

Small-scale

0.819

High

938425

NOP58
Nucleolar protein 58

2

9

High-throughput

0.802

High

938387

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

9

Small-scale

0.757

High

228694

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

11

High-throughput

0.691

High

938422

SRPK3
SRSF protein kinase 3

2

5

High-throughput

0.628

High

938325

NH2L1
NHP2-like protein 1

1

5

Small-scale

0.621

High

285160

EED
Polycomb protein EED

1

14

High-throughput

0.618

High

860100

RS9
Small ribosomal subunit protein uS4

1

4

High-throughput

0.618

High

938385

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.618

High

938411

DCA13
DDB1- and CUL4-associated factor 13

1

8

Small-scale

0.618

High

938347

RBM39
RNA-binding protein 39

2

3

High-throughput

0.611

High

938351

SUZ12
Polycomb protein SUZ12

2

1

High-throughput

0.601

High

128900

MEN1
Menin

2

2

High-throughput

0.584

High

371578

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.584

High

830425

CCNF
Cyclin-F

2

1

High-throughput

0.584

High

938357

EZH2
Histone-lysine N-methyltransferase EZH2

2

4

High-throughput

0.584

High

938371

MEPCE
7SK snRNA methylphosphate capping enzyme

2

1

High-throughput

0.584

High

938415

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

2

3

Small-scale

0.584

High

938360

SMN
Survival motor neuron protein

2

0

High-throughput

0.580

High

765290

BMI1
Polycomb complex protein BMI-1

2

8

High-throughput

0.571

High

934333

TERA
Transitional endoplasmic reticulum ATPase

2

4

High-throughput

0.571

High

938355

ZNHI3
Zinc finger HIT domain-containing protein 3

2

0

Small-scale

0.559

High

298587

RAD17
Cell cycle checkpoint protein RAD17

1

2

Small-scale

0.552

High

619645

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.549

High

842949

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

1

High-throughput

0.541

High

938336

RBM10
RNA-binding protein 10

1

2

High-throughput

0.541

High

938346

DPOA2
DNA polymerase alpha subunit B

1

2

High-throughput

0.541

High

431037

LA
Lupus La protein

1

7

High-throughput

0.536

High

477966

SNRPA
U1 small nuclear ribonucleoprotein A

1

3

High-throughput

0.536

High

574190

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

634377

LMNB1
Lamin-B1

1

2

High-throughput

0.536

High

667236

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

High-throughput

0.536

High

787952

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

938328

RUXF
Small nuclear ribonucleoprotein F

1

2

High-throughput

0.536

High

938329

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

6

High-throughput

0.536

High

938330

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

1

High-throughput

0.536

High

938331

SMD2
Small nuclear ribonucleoprotein Sm D2

1

2

High-throughput

0.536

High

938335

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

3

High-throughput

0.536

High

938350

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.536

High

938356

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

938359

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

2

High-throughput

0.536

High

938374

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.536

High

938375

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

High-throughput

0.536

High

938397

RBM42
RNA-binding protein 42

1

3

High-throughput

0.536

High

938409

STK36
Serine/threonine-protein kinase 36

1

4

High-throughput

0.536

High

938419

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

6

High-throughput

0.536

High

938428

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

4

High-throughput

0.536

High

557989

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.518

High

938340

TF3C1
General transcription factor 3C polypeptide 1

1

0

High-throughput

0.518

High

938395

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

2

High-throughput

0.515

High

480068

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

484457

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

541914

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

938332

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.513

High

938396

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

938344

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.508

High

938358

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.508

High

938400

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

High-throughput

0.494

High

389189

FINC
Fibronectin

1

2

High-throughput

0.489

High

938339

CALD1
Caldesmon

1

4

High-throughput

0.489

High

216239

PPIH
Peptidyl-prolyl cis-trans isomerase H

1

3

Small-scale

0.481

High

938363

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

1

High-throughput

0.481

High

131863

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

9

High-throughput

0.479

High

134622

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.479

High

170032

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

194074

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

222858

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

241217

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

247771

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

259692

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

297528

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

High-throughput

0.479

High

324678

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

400549

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

405946

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

472552

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

538916

EPB41
Protein 4.1

1

2

High-throughput

0.479

High

588321

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

606508

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

629689

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

667686

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.479

High

695048

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

767812

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

878841

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

887873

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

897679

CDK9
Cyclin-dependent kinase 9

1

4

High-throughput

0.479

High

907349

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

High-throughput

0.479

High

937675

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

938326

WDR5
WD repeat-containing protein 5

1

8

High-throughput

0.479

High

938327

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

938333

H4
Histone H4

1

2

High-throughput

0.479

High

938334

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.479

High

938337

VIGLN
Vigilin

1

3

High-throughput

0.479

High

938338

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

938341

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

5

High-throughput

0.479

High

938342

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

938343

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

938349

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

938352

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

938353

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

938354

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.479

High

938361

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

938362

LARP7
La-related protein 7

1

9

High-throughput

0.479

High

938364

RC3H1
Roquin-1

1

4

High-throughput

0.479

High

938367

IFIX
Pyrin and HIN domain-containing protein 1

1

5

High-throughput

0.479

High

938369

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.479

High

938372

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

938373

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

4

Small-scale

0.479

High

938376

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.479

High

938377

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

938380

NIN
Ninein

1

2

High-throughput

0.479

High

938382

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.479

High

938383

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

938386

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

938388

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

938389

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

938390

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.479

High

938392

MBD6
Methyl-CpG-binding domain protein 6

1

2

High-throughput

0.479

High

938394

RING2
E3 ubiquitin-protein ligase RING2

1

9

High-throughput

0.479

High

938401

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

938403

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

938404

LN28A
Protein lin-28 homolog A

1

8

High-throughput

0.479

High

938405

RC3H2
Roquin-2

1

5

High-throughput

0.479

High

938406

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

13

High-throughput

0.479

High

938408

ANLN
Anillin

1

1

High-throughput

0.479

High

938413

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

938414

MBD5
Methyl-CpG-binding domain protein 5

1

1

High-throughput

0.479

High

938417

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

938421

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.479

High

938423

CE164
Centrosomal protein of 164 kDa

1

4

High-throughput

0.479

High

938424

RUVB1
RuvB-like 1

1

3

Small-scale

0.479

High

938426

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

Small-scale

0.479

High

938427

TRAF6
TNF receptor-associated factor 6

1

6

High-throughput

0.479

High

938429

MAFB
Transcription factor MafB

1

2

High-throughput

0.479

High

791224

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

938381

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

Small-scale

0.458

High

938410

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

938370

RHOU
Rho-related GTP-binding protein RhoU

1

1

High-throughput

0.457

High

529436

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

938348

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.445

High

938365

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

157143

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.437

High

318683

RHBT1
Rho-related BTB domain-containing protein 1

1

2

High-throughput

0.437

High

377476

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

460474

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.437

High

565258

ITA4
Integrin alpha-4

1

1

High-throughput

0.437

High

938366

FTM
Protein fantom

1

4

High-throughput

0.437

High

938368

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

938379

CNTRB
Centrobin

1

2

High-throughput

0.437

High

938391

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.437

High

938399

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.437

High

938412

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

938420

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.437

High

938384

POC5
Centrosomal protein POC5

1

1

High-throughput

0.407

High

231070

CHST1
Carbohydrate sulfotransferase 1

1

0

High-throughput

0.282

High

938398

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

938345

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

0

High-throughput

0.269

Low

133009

MATN2
Matrilin-2

1

0

High-throughput

0.249

Low

938378

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

938393

KTI12
Protein KTI12 homolog

1

0

Small-scale

0.249

Low

938402

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

938407

NGB
Neuroglobin

1

0

High-throughput

0.249

Low

938416

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025