HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 192
+	Hs
		324783 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19
+	Hs
		324768 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01
+	Hs
		324789 M4K4_HUMAN (1-1239): 0: 1227: 100.00		RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83
+	Hs
		925434 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19
+	Mm
		925783 TNIK_MOUSE (1-1239): 0: 1120: 62.43		RAC1_MOUSE (1-192): 1.69e-84: 249: 92.19
+	Hs
		564611 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03
+	Hs
		545493 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00
+	Hs
		892483 MINK1_HUMAN (1-1239): 0: 1120: 59.29		RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01
+	Hs
		925356 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19
+	Hs
		564571 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03
+	Hs
		894128 MRCKG_HUMAN (13-974): 7.6e-138: 459: 17.29		CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75
+	Dm
		776947 GEK_DROME (15-983): 3.23e-136: 456: 13.20		CDC42_DROME (1-192): 1.03e-76: 229: 69.27
+	Hs
		647868 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19
+	Hs
		564418 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03
+	Hs
		545213 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00
+	Hs
		647855 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01
+	Hs
		647872 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83
+	Hs
		647856 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75
+	Hs
		647858 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26
+	Hs
		436165 MARK3_HUMAN (16-665): 4.1e-127: 411: 16.23		RHOC_HUMAN (5-192): 1.83e-73: 221: 54.79