HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 126
+	Hs
		324816 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		324778 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		324766 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		324840 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		148290 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		148588 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83
+	Hs
		148194 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		149215 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		149042 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		617927 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		420807 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		682181 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		682137 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Mm
		682111 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		H2B2B_MOUSE (1-126): 2.34e-54: 168: 97.62
+	Hs
		617926 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Mm
		682113 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		H2B1C_MOUSE (1-126): 1.18e-53: 166: 99.21
+	Hs
		420806 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		682194 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		149147 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		1150514 BRSK1_HUMAN (22-753): 9.31e-120: 391: 17.08		H2B2C_HUMAN (1-96): 1.25e-43: 143: 91.67