HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: H2B1D (P58876)
Histone H2B type 1-D (H2B-clustered histone 5) (HIRA-interacting protein 2) (Histone H2B.1 B) (Histone H2B.b) (H2B/b)
Gene: H2BC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 126
+	Hs
		324816 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B2F_HUMAN (1-126): 3.9e-54: 167: 97.62
+	Hs
		324812 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B2E_HUMAN (1-126): 9.91e-54: 166: 98.41
+	Hs
		324778 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B1C_HUMAN (1-126): 1.71e-53: 165: 99.21
+	Hs
		324840 M4K4_HUMAN (1-1239): 0: 1227: 100.00		H2B3B_HUMAN (1-126): 2.67e-51: 160: 95.24
+	Hs
		148290 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1J_HUMAN (1-126): 1.25e-53: 166: 97.62
+	Hs
		148194 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1K_HUMAN (1-126): 2.11e-53: 165: 98.41
+	Hs
		148588 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2BFS_HUMAN (1-126): 1.64e-53: 165: 96.83
+	Hs
		149215 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1L_HUMAN (1-126): 3.72e-52: 162: 97.62
+	Hs
		149042 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B3B_HUMAN (1-126): 2.67e-51: 160: 95.24
+	Hs
		420807 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1J_HUMAN (1-126): 1.25e-53: 166: 97.62
+	Hs
		617927 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1O_HUMAN (1-126): 5.42e-54: 166: 97.62
+	Hs
		682181 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B2E_HUMAN (1-126): 9.91e-54: 166: 98.41
+	Hs
		682137 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B1B_HUMAN (1-126): 1.77e-53: 165: 97.62
+	Mm
		682111 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		H2B2B_MOUSE (1-126): 3.9e-54: 167: 97.62
+	Hs
		420806 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		H2B1J_HUMAN (1-126): 1.25e-53: 166: 97.62
+	Hs
		617926 AKT1_HUMAN (2-354): 2.35e-122: 388: 20.82		H2B1O_HUMAN (1-126): 5.42e-54: 166: 97.62
+	Mm
		682113 AKT1_MOUSE (2-354): 1.36e-122: 389: 20.82		H2B1C_MOUSE (1-126): 1.71e-53: 165: 99.21
+	Hs
		682194 AKT2_HUMAN (2-354): 7.38e-124: 393: 21.98		H2B3B_HUMAN (1-126): 2.67e-51: 160: 95.24
+	Hs
		149147 CTRO_HUMAN (14-616): 3.12e-117: 405: 22.33		H2B1A_HUMAN (1-126): 5.53e-46: 146: 85.04
+	Hs
		1150514 BRSK1_HUMAN (22-753): 9.31e-120: 391: 17.08		H2B2C_HUMAN (1-96): 7.3e-44: 143: 89.58