HitPredict

Interactor 1: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Interactor 2: AMOT (Q4VCS5)
Angiomotin
Gene: AMOT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.728

Property	Details
Experiments	24366813, 30266805, 32292505, 34079125, 24255178, 24101513
Identification Methods	affinity chromatography technology, proximity labelling technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0035329 - hippo signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 1084
+	Hs
		1119070 LATS2_HUMAN (13-1121): 0: 751: 49.61		AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00
+	Hs
		325799 LATS1_HUMAN (1-1130): 0: 934: 100.00		AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98
+	Hs
		325955 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH4_HUMAN (350-812): 1.95e-39: 162: 15.92
+	Hs
		325609 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH7_HUMAN (250-667): 1.32e-15: 84.6: 9.81
+	Hs
		325611 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH6_HUMAN (273-669): 1.82e-15: 83.8: 10.08
+	Hs
		325608 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH1_HUMAN (381-687): 4.64e-14: 79.5: 13.69
+	Hs
		325935 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH2_HUMAN (381-687): 3.92e-14: 79.5: 14.01
+	Hs
		325612 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH8_HUMAN (382-687): 3.82e-13: 76.4: 13.10
+	Hs
		325936 LATS1_HUMAN (1-1130): 0: 934: 100.00		MYH13_HUMAN (435-755): 4.65e-12: 72.7: 20.63
+	Hs
		1222271 LATS2_HUMAN (13-1121): 0: 751: 49.61		AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98
+	Hs
		1344980 LATS2_HUMAN (13-1121): 0: 751: 49.61		AMOL2_HUMAN (296-902): 3.42e-27: 121: 39.81
+	Hs
		149340 LATS2_HUMAN (13-1121): 0: 751: 49.61		CTRO_HUMAN (533-815): 3.66e-12: 73.4: 12.37
+	Hs
		725079 ST38L_HUMAN (627-1089): 2.37e-167: 503: 40.82		MYH9_HUMAN (51-655): 1.51e-14: 81.1: 9.31
+	Hs
		681696 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		MYH9_HUMAN (51-655): 1.51e-14: 81.1: 9.31
+	Hs
		568567 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		MYH9_HUMAN (51-655): 1.51e-14: 81.1: 9.31
+	Hs
		681840 AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50		DCTN1_HUMAN (510-863): 3.81e-09: 63.3: 14.85
+	Hs
		568568 KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59		MYH10_HUMAN (479-879): 3.84e-12: 73: 12.04
+	Hs
		528359 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		MYH6_HUMAN (273-669): 1.82e-15: 83.8: 10.08
+	Hs
		522538 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		MYH1_HUMAN (381-687): 4.64e-14: 79.5: 13.69
+	Hs
		610795 KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58		MYH2_HUMAN (381-687): 3.92e-14: 79.5: 14.01