Protein: TMM33
Transmembrane protein 33 (Protein DB83) (SHINC-3)

Gene: TMM33, TMEM33
Organism: Homo sapiens
Interactions: 210
UniProt ID: P57088

Gene Ontology (top 5):
GO:0005635 - nuclear envelope
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0034976 - response to endoplasmic reticulum stress
GO:0042470 - melanosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

563497

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

High-throughput

0.662

High

869714

MTR1A
Melatonin receptor type 1A

3

1

Small-scale

0.621

High

241231

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

944317

RNF5
E3 ubiquitin-protein ligase RNF5

2

2

Small-scale

0.584

High

400559

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

1

High-throughput

0.578

High

944235

RHOA
Transforming protein RhoA

2

0

High-throughput

0.547

High

184150

RER1
Protein RER1

1

1

High-throughput

0.536

High

698534

CALX
Calnexin

1

1

High-throughput

0.536

High

813049

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.536

High

944344

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

944244

IFM3
Interferon-induced transmembrane protein 3

2

1

High-throughput

0.533

High

578432

BRAF
Serine/threonine-protein kinase B-raf

2

1

High-throughput

0.521

High

944315

M3K14
Mitogen-activated protein kinase kinase kinase 14

2

1

High-throughput

0.521

High

130053

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

322918

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

High-throughput

0.513

High

889954

PSN1
Presenilin-1

1

0

High-throughput

0.513

High

944285

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.513

High

944298

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

944300

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

944343

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.513

High

944357

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

417349

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

650108

FGFR3
Fibroblast growth factor receptor 3

1

3

High-throughput

0.479

High

786995

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

2

High-throughput

0.479

High

944253

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

944267

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

944282

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

High-throughput

0.479

High

944289

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

944295

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

944302

RN185
E3 ubiquitin-protein ligase RNF185

1

2

Small-scale

0.479

High

944321

RNF26
E3 ubiquitin-protein ligase RNF26

1

1

High-throughput

0.479

High

944324

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.479

High

944301

Q96FB2
SLC29A2 protein

1

1

High-throughput

0.470

High

179861

BET1
BET1 homolog

1

0

High-throughput

0.458

High

279136

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

319577

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

345579

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

536850

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

623213

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

720170

UFO
Tyrosine-protein kinase receptor UFO

1

0

High-throughput

0.458

High

773466

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.458

High

929860

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

934347

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

941888

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

944243

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

944247

CLN3
Battenin

1

0

Small-scale

0.458

High

944257

LBR
Delta(14)-sterol reductase LBR

1

0

Small-scale

0.458

High

944275

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

944277

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

944293

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

944303

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

944308

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

944319

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.458

High

944330

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

944331

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

944333

DJC18
DnaJ homolog subfamily C member 18

1

0

High-throughput

0.458

High

944336

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

944341

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

944291

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

944354

S27A5
Long-chain fatty acid transport protein 5

1

1

High-throughput

0.445

High

944255

S29A2
Equilibrative nucleoside transporter 2

1

1

High-throughput

0.439

High

325760

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

High-throughput

0.437

High

330800

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.437

High

342808

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.437

High

343242

ERR2
Steroid hormone receptor ERR2

1

1

High-throughput

0.437

High

411667

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

609975

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.437

High

766361

PHB1
Prohibitin 1

1

1

High-throughput

0.437

High

897682

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.437

High

944250

CUL3
Cullin-3

1

1

High-throughput

0.437

High

944251

CUL4B
Cullin-4B

1

1

High-throughput

0.437

High

944252

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.437

High

944254

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

944278

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

944297

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

944306

LMTK3
Serine/threonine-protein kinase LMTK3

1

3

High-throughput

0.437

High

944328

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.437

High

944339

RNF12
E3 ubiquitin-protein ligase RLIM

1

1

High-throughput

0.437

High

944342

WWOX
WW domain-containing oxidoreductase

1

3

High-throughput

0.437

High

279567

LAT3
Large neutral amino acids transporter small subunit 3

1

0

High-throughput

0.426

High

397924

ANGI
Angiogenin

1

0

High-throughput

0.426

High

421813

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.426

High

944325

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

97241

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

529449

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.407

High

765294

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.407

High

870440

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

1

High-throughput

0.407

High

944264

S4A8
Electroneutral sodium bicarbonate exchanger 1

1

4

High-throughput

0.407

High

944266

SL9C1
Solute carrier family 9 member C1

1

3

High-throughput

0.407

High

944270

SL9A4
Sodium/hydrogen exchanger 4

1

3

High-throughput

0.407

High

944274

S4A10
Sodium-driven chloride bicarbonate exchanger

1

4

High-throughput

0.407

High

944284

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.407

High

944286

SVOP
Synaptic vesicle 2-related protein

1

1

High-throughput

0.407

High

944288

S4A11
Solute carrier family 4 member 11

1

4

High-throughput

0.407

High

944292

CTL5
Choline transporter-like protein 5

1

1

High-throughput

0.407

High

944307

B3A4
Anion exchange protein 4

1

4

High-throughput

0.407

High

944313

SL9A7
Sodium/hydrogen exchanger 7

1

3

High-throughput

0.407

High

944318

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

1

High-throughput

0.407

High

944350

AGO2
Protein argonaute-2

1

1

High-throughput

0.407

High

944351

AGO1
Protein argonaute-1

1

1

High-throughput

0.407

High

944353

SL9A8
Sodium/hydrogen exchanger 8

1

3

High-throughput

0.407

High

944356

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

1

High-throughput

0.407

High

944359

S22A7
Solute carrier family 22 member 7

1

1

High-throughput

0.407

High

944360

S4A7
Sodium bicarbonate cotransporter 3

1

4

High-throughput

0.407

High

371590

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.334

High

588335

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.305

High

695065

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.305

High

767824

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.305

High

944322

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.305

High

584502

VAV
Proto-oncogene vav

2

0

High-throughput

0.298

High

622430

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

717273

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.298

High

878423

PAXI
Paxillin

2

0

High-throughput

0.298

High

905730

CAV2
Caveolin-2

2

0

High-throughput

0.298

High

944245

PAK1
Serine/threonine-protein kinase PAK 1

2

0

High-throughput

0.298

High

944246

MK07
Mitogen-activated protein kinase 7

2

0

High-throughput

0.298

High

944249

HDAC1
Histone deacetylase 1

2

0

High-throughput

0.298

High

944238

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.282

High

166639

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.279

Low

608240

EGLN
Endoglin

1

0

High-throughput

0.279

Low

944314

MPP8
M-phase phosphoprotein 8

1

0

High-throughput

0.279

Low

277336

TP4A3
Protein tyrosine phosphatase type IVA 3

1

0

High-throughput

0.269

Low

944236

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.269

Low

944265

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

0

High-throughput

0.269

Low

944316

NECD
Necdin

1

0

High-throughput

0.269

Low

944334

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.269

Low

105661

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

125362

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

157149

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

194077

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

279320

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

293446

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

315346

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

377479

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

458352

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

472290

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

538919

EPB41
Protein 4.1

1

0

High-throughput

0.249

Low

629693

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

642755

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

830438

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

878852

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

883194

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.249

Low

886383

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.249

Low

887879

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

897189

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.249

Low

904510

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

919845

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.249

Low

937680

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

944234

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

944237

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

944239

H4
Histone H4

1

0

High-throughput

0.249

Low

944240

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.249

Low

944241

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

944242

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

944248

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

944258

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.249

Low

944259

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

944260

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.249

Low

944261

FSCN1
Fascin

1

0

High-throughput

0.249

Low

944262

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.249

Low

944263

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

944268

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

944269

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

944271

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

944272

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

944276

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

944279

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.249

Low

944280

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

944281

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.249

Low

944283

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

944287

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

944290

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

944294

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

944296

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

944304

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

944305

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

944309

CIC
Protein capicua homolog

1

0

High-throughput

0.249

Low

944311

OXLA
L-amino-acid oxidase

1

0

Small-scale

0.249

Low

944312

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.249

Low

944323

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.249

Low

944326

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.249

Low

944327

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.249

Low

944329

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

944332

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

944335

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

944337

ANLN
Anillin

1

0

High-throughput

0.249

Low

944338

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

944340

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

944345

ARP3B
Actin-related protein 3B

1

0

High-throughput

0.249

Low

944346

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low

944347

TRM7
tRNA

1

0

High-throughput

0.249

Low

944348

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

944352

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low

944355

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

944358

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low

992

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

65409

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

0

High-throughput

0.232

Low

143419

E2F3
Transcription factor E2F3

1

0

Small-scale

0.232

Low

256016

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

344144

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

410742

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.232

Low

653223

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

841123

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

844917

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.232

Low

944256

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.232

Low

944273

S39A4
Zinc transporter ZIP4

1

0

High-throughput

0.232

Low

944299

FUCT1
GDP-fucose transporter 1

1

0

High-throughput

0.232

Low

944310

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low

944320

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.232

Low

944349

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025