Protein: XPO2
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)

Gene: XPO2, CSE1L
Organism: Homo sapiens
Interactions: 244
UniProt ID: P55060

Gene Ontology (top 5):
GO:0005049 - nuclear export signal receptor activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

853218

IMA1
Importin subunit alpha-1

3

14

Small-scale

0.840

High

874486

RAC1
Ras-related C3 botulinum toxin substrate 1

3

13

High-throughput

0.817

High

853551

IMA5
Importin subunit alpha-5

2

14

Small-scale

0.799

High

874474

CDC42
Cell division control protein 42 homolog

2

14

High-throughput

0.768

High

226978

PRKN
E3 ubiquitin-protein ligase parkin

4

11

High-throughput

0.686

High

338188

EGFR
Epidermal growth factor receptor

4

10

Small-scale

0.676

High

874523

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

6

Small-scale

0.657

High

346330

MYC
Myc proto-oncogene protein

3

5

High-throughput

0.656

High

528833

CFTR
Cystic fibrosis transmembrane conductance regulator

3

8

High-throughput

0.650

High

134861

IMA3
Importin subunit alpha-3

1

14

Small-scale

0.647

High

874484

RAN
GTP-binding nuclear protein Ran

1

19

Small-scale

0.647

High

120366

RHOD
Rho-related GTP-binding protein RhoD

1

17

High-throughput

0.618

High

162547

XPO1
Exportin-1

1

8

Small-scale

0.618

High

391615

H2A1B
Histone H2A type 1-B/E

1

9

High-throughput

0.618

High

727228

NU214
Nuclear pore complex protein Nup214

1

11

Small-scale

0.618

High

852416

RND2
Rho-related GTP-binding protein RhoN

1

14

High-throughput

0.618

High

874476

UBC12
NEDD8-conjugating enzyme Ubc12

1

5

High-throughput

0.618

High

874477

RHOA
Transforming protein RhoA

1

14

High-throughput

0.618

High

874481

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.618

High

874482

RHOB
Rho-related GTP-binding protein RhoB

1

14

High-throughput

0.618

High

874516

RHOH
Rho-related GTP-binding protein RhoH

1

14

High-throughput

0.618

High

874585

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

8

High-throughput

0.618

High

874588

RHOJ
Rho-related GTP-binding protein RhoJ

1

14

High-throughput

0.618

High

874594

RHOF
Rho-related GTP-binding protein RhoF

1

16

High-throughput

0.618

High

274079

XRP2
Protein XRP2

2

5

High-throughput

0.611

High

501874

BIP
Endoplasmic reticulum chaperone BiP

2

5

High-throughput

0.611

High

617045

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

2

12

High-throughput

0.611

High

874498

G3BP1
Ras GTPase-activating protein-binding protein 1

2

7

High-throughput

0.611

High

874565

VSIG2
V-set and immunoglobulin domain-containing protein 2

2

6

High-throughput

0.611

High

874611

NUP50
Nuclear pore complex protein Nup50

2

12

High-throughput

0.611

High

779096

CCNF
Cyclin-F

2

6

High-throughput

0.601

High

521829

CADH1
Cadherin-1

2

0

Small-scale

0.598

High

487266

ANDR
Androgen receptor

2

6

High-throughput

0.584

High

577005

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

11

High-throughput

0.584

High

874491

EP300
Histone acetyltransferase p300

2

17

High-throughput

0.584

High

874511

SUZ12
Polycomb protein SUZ12

2

1

High-throughput

0.584

High

874517

EZH2
Histone-lysine N-methyltransferase EZH2

2

4

High-throughput

0.584

High

874593

WDR76
WD repeat-containing protein 76

2

8

High-throughput

0.584

High

874596

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

3

High-throughput

0.584

High

874606

HDAC6
Histone deacetylase 6

2

7

Small-scale

0.584

High

874592

PACC1
Proton-activated chloride channel

2

6

High-throughput

0.574

High

581577

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

726680

FUS
RNA-binding protein FUS

2

5

High-throughput

0.571

High

874485

GRB2
Growth factor receptor-bound protein 2

2

3

High-throughput

0.571

High

874563

OTUB1
Ubiquitin thioesterase OTUB1

2

1

High-throughput

0.571

High

874503

BIRC2
Baculoviral IAP repeat-containing protein 2

1

8

Small-scale

0.561

High

874473

TPTE
Putative tyrosine-protein phosphatase TPTE

1

7

High-throughput

0.554

High

874567

RHOV
Rho-related GTP-binding protein RhoV

1

17

High-throughput

0.553

High

874583

RHBT2
Rho-related BTB domain-containing protein 2

1

15

High-throughput

0.553

High

874571

MMS19
MMS19 nucleotide excision repair protein homolog

2

0

Small-scale

0.547

High

540941

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

4

High-throughput

0.541

High

722349

RL22
Large ribosomal subunit protein eL22

1

1

High-throughput

0.541

High

858600

PPP5
Serine/threonine-protein phosphatase 5

1

2

High-throughput

0.541

High

874518

MK06
Mitogen-activated protein kinase 6

1

8

High-throughput

0.541

High

386384

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

171967

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.536

High

196755

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.536

High

299872

ERLN2
Erlin-2

1

6

Small-scale

0.536

High

306779

VAMP5
Vesicle-associated membrane protein 5

1

2

High-throughput

0.536

High

505370

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

595162

LMNB1
Lamin-B1

1

3

High-throughput

0.536

High

598930

FPR1
fMet-Leu-Phe receptor

1

14

High-throughput

0.536

High

639567

TNR5
Tumor necrosis factor receptor superfamily member 5

1

10

High-throughput

0.536

High

646150

STOM
Stomatin

1

7

High-throughput

0.536

High

702207

CD70
CD70 antigen

1

2

High-throughput

0.536

High

734899

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

11

High-throughput

0.536

High

794372

GRK6
G protein-coupled receptor kinase 6

1

6

High-throughput

0.536

High

874475

SRP54
Signal recognition particle subunit SRP54

1

2

High-throughput

0.536

High

874490

KPCZ
Protein kinase C zeta type

1

7

High-throughput

0.536

High

874501

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

Small-scale

0.536

High

874504

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

874507

MAP7
Ensconsin

1

12

High-throughput

0.536

High

874527

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.536

High

874537

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

7

High-throughput

0.536

High

874538

RBM45
RNA-binding protein 45

1

5

High-throughput

0.536

High

874541

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

3

High-throughput

0.536

High

874544

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.536

High

874546

COQ8A
Atypical kinase COQ8A, mitochondrial

1

1

High-throughput

0.536

High

874547

KI18A
Kinesin-like protein KIF18A

1

2

High-throughput

0.536

High

874552

AQP3
Aquaporin-3

1

4

High-throughput

0.536

High

874572

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

874615

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

7

High-throughput

0.536

High

874492

TMM62
Transmembrane protein 62

1

0

High-throughput

0.518

High

874607

DUX4
Double homeobox protein 4

1

1

High-throughput

0.516

High

301371

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

3

High-throughput

0.515

High

455263

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.515

High

150481

ENPP3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

1

0

High-throughput

0.513

High

874524

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

646750

1433T
14-3-3 protein theta

1

12

High-throughput

0.501

High

874478

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

874578

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.500

High

238855

TPST2
Protein-tyrosine sulfotransferase 2

1

3

High-throughput

0.489

High

686275

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

6

High-throughput

0.489

High

874500

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.489

High

874515

P2RY6
P2Y purinoceptor 6

1

20

High-throughput

0.489

High

874560

FAF2
FAS-associated factor 2

1

4

High-throughput

0.489

High

874569

OPALI
Opalin

1

3

High-throughput

0.489

High

874580

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

874587

UN93B
Protein unc-93 homolog B1

1

5

High-throughput

0.489

High

874620

GPR45
Probable G-protein coupled receptor 45

1

14

High-throughput

0.489

High

874621

NPTN
Neuroplastin

1

10

High-throughput

0.489

High

874576

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.479

High

135413

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.479

High

148578

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.479

High

242031

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

244174

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

294582

RECQ4
ATP-dependent DNA helicase Q4

1

12

High-throughput

0.479

High

299343

UBXN7
UBX domain-containing protein 7

1

4

High-throughput

0.479

High

322378

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

326536

SNAI1
Zinc finger protein SNAI1

1

20

High-throughput

0.479

High

362973

FINC
Fibronectin

1

1

High-throughput

0.479

High

369253

ESR1
Estrogen receptor

1

6

High-throughput

0.479

High

373940

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

397869

ISG15
Ubiquitin-like protein ISG15

1

8

High-throughput

0.479

High

530531

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

546831

PPAP
Prostatic acid phosphatase

1

1

High-throughput

0.479

High

552339

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

568602

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

5

Small-scale

0.479

High

569462

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

591291

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

10

High-throughput

0.479

High

622414

CCND1
G1/S-specific cyclin-D1

1

2

High-throughput

0.479

High

625267

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

648696

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

650784

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

660841

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

11

High-throughput

0.479

High

668545

PML
Protein PML

1

10

High-throughput

0.479

High

673046

CCND2
G1/S-specific cyclin-D2

1

2

Small-scale

0.479

High

684559

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.479

High

720072

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

726106

BASI
Basigin

1

10

High-throughput

0.479

High

749284

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

790649

WASP
Actin nucleation-promoting factor WAS

1

3

Small-scale

0.479

High

799067

NKX21
Homeobox protein Nkx-2.1

1

1

High-throughput

0.479

High

802543

CRK
Adapter molecule crk

1

3

Small-scale

0.479

High

819606

NRIP1
Nuclear receptor-interacting protein 1

1

1

Small-scale

0.479

High

832265

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

835609

GSK3B
Glycogen synthase kinase-3 beta

1

6

High-throughput

0.479

High

842097

R144A
E3 ubiquitin-protein ligase RNF144A

1

1

Small-scale

0.479

High

868095

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

874472

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

874479

WDR5
WD repeat-containing protein 5

1

8

High-throughput

0.479

High

874480

1433G
14-3-3 protein gamma

1

12

High-throughput

0.479

High

874483

H4
Histone H4

1

3

High-throughput

0.479

High

874487

1433Z
14-3-3 protein zeta/delta

1

12

High-throughput

0.479

High

874488

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

874489

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.479

High

874496

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

7

High-throughput

0.479

High

874497

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

3

High-throughput

0.479

High

874502

BIRC3
Baculoviral IAP repeat-containing protein 3

1

8

High-throughput

0.479

High

874505

CUL3
Cullin-3

1

8

High-throughput

0.479

High

874508

RBM39
RNA-binding protein 39

1

4

High-throughput

0.479

High

874510

HAPR1
HUWE1-associated protein modifying stress responses 1

1

4

High-throughput

0.479

High

874512

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

874513

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

874514

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

874519

CAH9
Carbonic anhydrase 9

1

7

Small-scale

0.479

High

874520

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

17

High-throughput

0.479

High

874521

ANR55
Ankyrin repeat domain-containing protein 55

1

3

High-throughput

0.479

High

874522

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

874525

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

874526

CDC73
Parafibromin

1

1

High-throughput

0.479

High

874531

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

874532

MOB3C
MOB kinase activator 3C

1

5

High-throughput

0.479

High

874534

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

874535

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

874536

ZN598
E3 ubiquitin-protein ligase ZNF598

1

7

High-throughput

0.479

High

874539

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

874540

RHG24
Rho GTPase-activating protein 24

1

6

High-throughput

0.479

High

874542

NGEF
Ephexin-1

1

4

High-throughput

0.479

High

874548

FBX25
F-box only protein 25

1

2

High-throughput

0.479

High

874549

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

10

High-throughput

0.479

High

874553

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

874556

FBXW7
F-box/WD repeat-containing protein 7

1

6

Small-scale

0.479

High

874557

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

9

Small-scale

0.479

High

874558

ARMC5
Armadillo repeat-containing protein 5

1

7

High-throughput

0.479

High

874559

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

874562

SPDLY
Protein Spindly

1

2

High-throughput

0.479

High

874564

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.479

High

874568

ASB16
Ankyrin repeat and SOCS box protein 16

1

1

High-throughput

0.479

High

874570

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

874573

RING2
E3 ubiquitin-protein ligase RING2

1

7

High-throughput

0.479

High

874574

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

874575

RIOK1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

874577

DUS23
Dual specificity protein phosphatase 23

1

15

High-throughput

0.479

High

874579

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

12

High-throughput

0.479

High

874581

DUS16
Dual specificity protein phosphatase 16

1

4

High-throughput

0.479

High

874582

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.479

High

874586

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

874589

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

874591

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

874595

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

4

High-throughput

0.479

High

874597

ANLN
Anillin

1

7

High-throughput

0.479

High

874598

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

874599

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

874600

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

874601

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

874603

TLS1
Splicing factor C9orf78

1

6

High-throughput

0.479

High

874604

PD1L1
Programmed cell death 1 ligand 1

1

18

Small-scale

0.479

High

874608

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

874609

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

874610

AMFR
E3 ubiquitin-protein ligase AMFR

1

7

Small-scale

0.479

High

874613

TRI33
E3 ubiquitin-protein ligase TRIM33

1

11

High-throughput

0.479

High

874614

HDAC5
Histone deacetylase 5

1

7

High-throughput

0.479

High

874623

NEMO
NF-kappa-B essential modulator

1

3

High-throughput

0.479

High

329541

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

825675

MTR1B
Melatonin receptor type 1B

1

6

High-throughput

0.464

High

298319

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

303048

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

874493

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.458

High

874499

CLN3
Battenin

1

0

Small-scale

0.458

High

874506

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

874543

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

874551

TM171
Transmembrane protein 171

1

0

High-throughput

0.458

High

874605

RN181
E3 ubiquitin-protein ligase RNF181

1

0

High-throughput

0.458

High

874618

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

874619

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.458

High

321026

PTBP3
Polypyrimidine tract-binding protein 3

1

5

High-throughput

0.445

High

394407

A4
Amyloid-beta precursor protein

1

3

Small-scale

0.445

High

401703

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

496647

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

874495

STK4
Serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

874509

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.445

High

874555

ESR2
Estrogen receptor beta

1

6

High-throughput

0.445

High

874584

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

384564

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

874528

LMBRL
Protein LMBR1L

1

4

High-throughput

0.437

High

874530

RHG36
Rho GTPase-activating protein 36

1

5

High-throughput

0.437

High

874533

KCTD9
BTB/POZ domain-containing protein KCTD9

1

2

High-throughput

0.437

High

874550

DEP1B
DEP domain-containing protein 1B

1

7

High-throughput

0.437

High

874554

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

11

High-throughput

0.437

High

874602

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

4

High-throughput

0.437

High

874612

HECD1
E3 ubiquitin-protein ligase HECTD1

1

5

High-throughput

0.437

High

874616

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

874529

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

874617

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

Small-scale

0.426

High

991

SIM26
Small integral membrane protein 26

1

6

High-throughput

0.407

High

874545

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

69677

HACD1
Very-long-chain

1

0

High-throughput

0.279

Low

874494

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

874561

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

874566

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

1

0

High-throughput

0.279

Low

874590

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

874622

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

541234

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024