HitPredict

Interactor 1: CBX7 (O95931)
Chromobox protein homolog 7
Gene: CBX7

Interactor 2: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.957

Property	Details
Experiments	28514442, 27705803, 33961781, 33664452, 19636380, 21282530
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 251 Hs			1 344
+	Hs
		327830 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		123194 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF2_HUMAN (1-344): 8.96e-118: 345: 100.00
+	Mm
		223225 CBX4_MOUSE (1-242): 9.5e-58: 194: 33.60		PCGF2_MOUSE (1-342): 3.16e-110: 326: 95.91
+	Hs
		123193 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		327845 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF3_HUMAN (4-230): 3.51e-66: 210: 33.48
+	Hs
		327860 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42
+	Hs
		327861 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Dr
		1186372 Q804D1_DANRE (1-175): 1.64e-41: 149: 35.75		BMI1B_DANRE (1-341): 4.72e-92: 279: 59.18
+	Hs
		327851 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		PCGF5_HUMAN (1-221): 5.43e-53: 177: 31.88
+	Hs
		327858 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		RING2_HUMAN (4-234): 2.68e-45: 159: 17.49
+	Hs
		123257 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF3_HUMAN (4-230): 3.51e-66: 210: 33.48
+	Hs
		123312 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42
+	Hs
		123317 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Hs
		123273 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		PCGF5_HUMAN (1-221): 5.43e-53: 177: 31.88
+	Hs
		327842 CBX7_HUMAN (1-251): 1.05e-81: 247: 100.00		RING1_HUMAN (3-127): 4.75e-28: 114: 23.26
+	Mm
		223231 CBX4_MOUSE (1-242): 9.5e-58: 194: 33.60		RING2_MOUSE (4-234): 2.19e-45: 159: 17.49
+	Hs
		123308 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		RING2_HUMAN (4-234): 2.68e-45: 159: 17.49
+	Hs
		123174 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		RO52_HUMAN (8-210): 4.32e-32: 127: 15.02
+	Mm
		1164651 Q6TKP2_MOUSE (1-198): 5.13e-41: 150: 32.29		RING2_MOUSE (4-234): 2.19e-45: 159: 17.49
+	Hs
		123243 CBX4_HUMAN (1-242): 2.24e-55: 187: 33.60		RING1_HUMAN (3-127): 4.75e-28: 114: 23.26