Protein: CBS
Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) (Sulfur transfer protein 4)

Gene: CBS, CYS4
Organism: Saccharomyces cerevisiae S288C
Interactions: 124
UniProt ID: P32582

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0004122 - cystathionine beta-synthase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0006535 - cysteine biosynthetic process from serine

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

392434

HSP82
ATP-dependent molecular chaperone HSP82

3

9

Small-scale

0.633

High

510317

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.611

High

740639

HSP7F
Heat shock protein homolog SSE1

2

9

High-throughput

0.601

High

579059

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.584

High

740672

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

740638

CBS
Cystathionine beta-synthase

1

19

Small-scale

0.575

High

726859

HS104
Heat shock protein 104

2

5

High-throughput

0.571

High

526210

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

740668

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

670486

SIS1
Protein SIS1

2

3

High-throughput

0.549

High

364419

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.536

High

574655

KSS1
Mitogen-activated protein kinase KSS1

1

5

High-throughput

0.536

High

597080

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

656398

KC11
Casein kinase I homolog 1

1

3

High-throughput

0.536

High

394370

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.515

High

470491

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.515

High

486100

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.515

High

592113

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.515

High

740688

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

3

High-throughput

0.515

High

444839

SIR3
Regulatory protein SIR3

1

0

High-throughput

0.513

High

639548

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.513

High

709326

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

726197

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

High-throughput

0.513

High

740663

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.500

High

740664

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

2

High-throughput

0.500

High

386637

TBB
Tubulin beta chain

1

0

High-throughput

0.493

High

740647

SLD2
DNA replication regulator SLD2

1

0

High-throughput

0.493

High

740657

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.493

High

740671

ERR3
Enolase-related protein 3

1

0

High-throughput

0.493

High

740690

WAR1
Weak acid resistance protein 1

1

0

High-throughput

0.493

High

740696

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.489

High

740706

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.479

High

149658

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

434938

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

464579

PBS2
MAP kinase kinase PBS2

1

3

High-throughput

0.479

High

514529

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

558645

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

649586

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.479

High

674496

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

679498

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

737805

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

740642

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

740643

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.479

High

740648

TCTP
Translationally-controlled tumor protein homolog

1

1

High-throughput

0.479

High

740649

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

740651

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.479

High

740653

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

740676

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

740683

HST2
NAD-dependent protein deacetylase HST2

1

1

High-throughput

0.479

High

740689

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

678858

CSM1
Monopolin complex subunit CSM1

1

1

High-throughput

0.464

High

623805

MYO2
Myosin-2

1

0

Small-scale

0.460

High

740684

RHO5
GTP-binding protein RHO5

1

0

Small-scale

0.460

High

365586

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

441790

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

448888

TYSY
Thymidylate synthase

1

0

High-throughput

0.458

High

677021

GID7
GID complex subunit 7

1

0

High-throughput

0.458

High

740641

TCA17
TRAPP-associated protein TCA17

1

0

Small-scale

0.458

High

740644

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

740661

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

740665

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

740667

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

740670

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

740677

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

740679

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

740681

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.458

High

740687

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

740655

TCD1
tRNA threonylcarbamoyladenosine dehydratase 1

1

2

High-throughput

0.457

High

575320

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.457

High

624986

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.457

High

481540

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

523395

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

544211

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

577071

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.445

High

675828

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

740656

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

740666

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

740673

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

740674

DPH4
Diphthamide biosynthesis protein 4

1

2

High-throughput

0.445

High

740686

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.445

High

740682

YG3A
Uncharacterized protein YGR130C

1

0

High-throughput

0.438

High

740705

RTN2
Reticulon-like protein 2

1

0

High-throughput

0.438

High

383590

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

410010

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433526

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

502927

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504111

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

689342

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

706545

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

740662

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

740691

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.437

High

740698

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

740699

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

740704

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

740675

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

740685

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

740692

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.426

High

740702

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

740660

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.407

High

740701

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.288

High

740646

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

448153

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.279

Low

449404

SPT2
Protein SPT2

1

0

High-throughput

0.279

Low

586443

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.279

Low

688786

RFA3
Replication factor A protein 3

1

0

High-throughput

0.279

Low

740659

TEM1
Protein TEM1

1

0

High-throughput

0.279

Low

740669

SEC24
Protein transport protein SEC24

1

0

High-throughput

0.279

Low

740678

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

740694

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

528569

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.269

Low

740640

STH1
Nuclear protein STH1/NPS1

1

0

High-throughput

0.269

Low

672225

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

740703

ATG5
Autophagy protein 5

1

0

High-throughput

0.261

Low

740645

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

740650

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

740652

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.249

Low

740654

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

740658

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

740680

DRN1
CWF19-like protein DRN1

1

0

High-throughput

0.249

Low

740693

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

740695

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

740697

EXP1
ER export of PMA1 protein 1

1

0

High-throughput

0.249

Low

740700

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025