HitPredict

Interactor 1: ITGBL (O95965)
Integrin beta-like protein 1 (Osteoblast-specific cysteine-rich protein) (Ten integrin EGF-like repeat domain-containing protein)
Gene: ITGBL1

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 1731
+	Mm
		1116017 TENR_MOUSE (308-493): 2.08e-23: 106: 21.28		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Hs
		980523 NOTC2_HUMAN (280-494): 2.62e-15: 81.4: 14.88		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		61630 MEG11_HUMAN (2-285): 8.43e-15: 79.5: 15.57		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		254237 MEGF6_HUMAN (17-486): 1.22e-13: 76: 14.98		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1296145 MEG10_HUMAN (2-292): 1.79e-13: 75.3: 12.15		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		804330 NOTC1_HUMAN (277-494): 1.48e-12: 72.6: 15.14		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316311 NOTC3_HUMAN (323-494): 3.61e-11: 68: 15.70		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Dm
		246781 TENM_DROME (2-112): 5.91e-09: 61: 13.08		Q0KIE7_DROME (30-505): 2.28e-87: 318: 16.35
+	Hs
		166914 NOTC2_HUMAN (280-494): 2.62e-15: 81.4: 14.88		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		167042 NOTC3_HUMAN (323-494): 3.61e-11: 68: 15.70		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Dm
		65546 NOTCH_DROME (1-277): 4.29e-12: 71: 11.43		A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17
+	Hs
		980449 NOTC2_HUMAN (280-494): 2.62e-15: 81.4: 14.88		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		944122 JAG1_HUMAN (116-494): 5.58e-21: 98.8: 15.72		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Hs
		804293 NOTC1_HUMAN (277-494): 1.48e-12: 72.6: 15.14		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		1237561 NOTC3_HUMAN (323-494): 3.61e-11: 68: 15.70		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Dm
		114000 CUBN_DROME (5-319): 3.54e-18: 90.3: 16.18		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73
+	Hs
		1231741 SORL_HUMAN (222-490): 4.51e-10: 64.5: 13.55		AN36B_HUMAN (67-198): 2.66e-16: 87.4: 18.18
+	Mm
		1193398 JAG1_MOUSE (217-492): 2.75e-10: 65.3: 15.28		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Dm
		422915 NOTCH_DROME (1-277): 4.29e-12: 71: 11.43		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31