HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0006915 - apoptotic process GO:0007165 - signal transduction GO:0045766 - positive regulation of angiogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 196
+	Hs
		330967 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		330835 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57
+	Hs
		330976 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53
+	Hs
		330930 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54
+	Hs
		330933 PAK4_HUMAN (1-591): 0: 586: 100.00		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Hs
		330841 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74
+	Hs
		120266 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOD_HUMAN (7-182): 3.37e-66: 203: 53.98
+	Hs
		925648 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10
+	Hs
		894474 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49
+	Dm
		776946 PAKM_DROME (1-589): 9.31e-163: 480: 48.82		CDC42_DROME (1-196): 3.02e-74: 223: 49.49
+	Dm
		1177643 PAK_DROME (8-589): 9.88e-153: 457: 34.09		Q7JWS8_DROME (1-196): 8.76e-78: 232: 51.78
+	Dm
		776915 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC1_DROME (1-196): 1.58e-77: 231: 53.06
+	Dm
		819751 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC2_DROME (1-196): 6.51e-76: 227: 53.06
+	Dm
		776941 PAK_DROME (8-589): 9.88e-153: 457: 34.09		CDC42_DROME (1-196): 3.02e-74: 223: 49.49
+	Dm
		776912 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC1_DROME (1-196): 1.58e-77: 231: 53.06
+	Dm
		819750 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC2_DROME (1-196): 6.51e-76: 227: 53.06
+	Dm
		776940 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		CDC42_DROME (1-196): 3.02e-74: 223: 49.49
+	Ce
		975572 PK1_CAEEL (2-589): 1.24e-122: 375: 31.38		RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57
+	Sp
		963937 SHK2_SCHPO (69-585): 2.2e-118: 365: 30.84		CDC42_SCHPO (1-196): 2.54e-76: 228: 50.51
+	Hs
		564425 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74