HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	26598620, 31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 236
+	Hs
		331035 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		330976 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		330967 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		330930 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		330841 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		330835 PAK4_HUMAN (1-591): 0: 586: 100.00		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		330933 PAK4_HUMAN (1-591): 0: 586: 100.00		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		331085 PAK4_HUMAN (1-591): 0: 586: 100.00		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		1296744 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00
+	Hs
		925648 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		894474 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Dm
		776946 PAKM_DROME (1-589): 9.31e-163: 480: 48.82		CDC42_DROME (32-207): 2.91e-67: 207: 56.82
+	Dm
		776915 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC1_DROME (32-217): 4.08e-74: 224: 53.76
+	Dm
		819751 PAK_DROME (8-589): 9.88e-153: 457: 34.09		RAC2_DROME (32-217): 2.42e-73: 222: 53.76
+	Dm
		1177643 PAK_DROME (8-589): 9.88e-153: 457: 34.09		Q7JWS8_DROME (30-217): 3.23e-72: 220: 50.53
+	Hs
		1330933 PAK6_HUMAN (1-591): 2.91e-166: 491: 45.72		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Dm
		776941 PAK_DROME (8-589): 9.88e-153: 457: 34.09		CDC42_DROME (32-207): 2.91e-67: 207: 56.82
+	Dm
		776912 Q9VEV1_DROME (2-589): 7.2e-141: 422: 28.74		RAC1_DROME (32-217): 4.08e-74: 224: 53.76
+	Sc
		580325 CLA4_YEAST (1-586): 6.09e-144: 439: 25.83		CDC42_YEAST (32-207): 5.04e-64: 199: 55.11
+	Sc
		580329 STE20_YEAST (11-591): 6.96e-143: 439: 31.62		CDC42_YEAST (32-207): 5.04e-64: 199: 55.11