HitPredict

Interactor 1: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24255178
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0106310 - protein serine kinase activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 1088
+	Hs
		1027443 STK3_HUMAN (289-588): 1.76e-123: 374: 35.43		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1023124 STK4_HUMAN (298-588): 1.44e-122: 372: 35.50		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Mm
		1186777 STK4_MOUSE (298-588): 2.88e-126: 382: 35.50		LATS2_MOUSE (1-1088): 0: 876: 80.66
+	Hs
		1344955 STK26_HUMAN (315-574): 2.21e-52: 186: 38.31		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Mm
		1207483 STK4_MOUSE (298-588): 2.88e-126: 382: 35.50		LATS1_MOUSE (1-1082): 0: 735: 49.61
+	Hs
		325714 STK3_HUMAN (289-588): 1.76e-123: 374: 35.43		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		325711 STK4_HUMAN (298-588): 1.44e-122: 372: 35.50		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		331011 PAK4_HUMAN (1-591): 0: 586: 100.00		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Sc
		865844 STE20_YEAST (11-591): 6.96e-143: 439: 31.62		CBK1_YEAST (347-1051): 3.83e-143: 450: 29.56
+	Hs
		681681 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		682218 AKT2_HUMAN (261-583): 1.6e-127: 384: 22.94		AKT3_HUMAN (532-1043): 3.66e-141: 435: 22.01
+	Hs
		681822 STK3_HUMAN (289-588): 1.76e-123: 374: 35.43		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		681817 STK4_HUMAN (298-588): 1.44e-122: 372: 35.50		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		681859 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Mm
		578256 KS6A3_MOUSE (265-591): 4.82e-113: 355: 24.27		KS6A3_MOUSE (519-990): 1.01e-80: 281: 19.63
+	Hs
		850621 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		850655 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		1073422 KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		254459 KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27		ROCK2_HUMAN (640-1008): 6.33e-67: 248: 36.90