Protein: ZN451
E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)

Gene: ZN451, ZNF451
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q9Y4E5

Gene Ontology (top 5):
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0008270 - zinc ion binding
GO:0016605 - PML body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

993829

UBC9
SUMO-conjugating enzyme UBC9

6

1

Small-scale

0.735

High

542704

TOP2A
DNA topoisomerase 2-alpha

3

1

Small-scale

0.667

High

414911

P53
Cellular tumor antigen p53

3

5

High-throughput

0.640

High

1447988

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

3

High-throughput

0.628

High

508888

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

5

Small-scale

0.602

High

714549

PML
Protein PML

2

20

Small-scale

0.595

High

1404541

CDC5L
Cell division cycle 5-like protein

2

0

High-throughput

0.565

High

520481

ANDR
Androgen receptor

1

17

Small-scale

0.552

High

272779

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

2

High-throughput

0.541

High

593251

CREB1
Cyclic AMP-responsive element-binding protein 1

1

2

High-throughput

0.541

High

844128

HD
Huntingtin

1

1

High-throughput

0.541

High

900570

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.541

High

939241

SUMO3
Small ubiquitin-related modifier 3

1

2

High-throughput

0.541

High

1095862

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.541

High

343118

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.536

High

407737

S100B
Protein S100-B

1

2

High-throughput

0.536

High

1039591

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.536

High

1433815

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

1364902

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

2

High-throughput

0.526

High

771946

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.518

High

911897

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.518

High

533804

CLUS
Clusterin

1

0

High-throughput

0.513

High

1144232

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

216571

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

High-throughput

0.508

High

1239698

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

High-throughput

0.508

High

1407974

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.508

High

964524

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

991467

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.501

High

1336985

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.501

High

1328779

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

1

High-throughput

0.494

High

247053

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.486

High

1417034

CDCA4
Cell division cycle-associated protein 4

1

0

High-throughput

0.486

High

297718

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

Small-scale

0.481

High

297886

PIAS2
E3 SUMO-protein ligase PIAS2

1

1

Small-scale

0.481

High

1281501

ZN467
Zinc finger protein 467

1

12

High-throughput

0.481

High

1368538

CBP
CREB-binding protein

1

8

Small-scale

0.481

High

1460667

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

9

High-throughput

0.481

High

1491394

ZN451
E3 SUMO-protein ligase ZNF451

1

7

Small-scale

0.481

High

260649

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

373600

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

401758

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

487920

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

679300

DNJB1
DnaJ homolog subfamily B member 1

1

4

High-throughput

0.479

High

834102

HNF4A
Hepatocyte nuclear factor 4-alpha

1

8

High-throughput

0.479

High

883743

CENPA
Histone H3-like centromeric protein A

1

13

High-throughput

0.479

High

1005279

RNF4
E3 ubiquitin-protein ligase RNF4

1

12

High-throughput

0.479

High

1017331

H33
Histone H3.3

1

13

High-throughput

0.479

High

1036021

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

1088126

NFIA
Nuclear factor 1 A-type

1

13

High-throughput

0.479

High

1089078

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1097651

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1114741

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1133756

NFIX
Nuclear factor 1 X-type

1

13

High-throughput

0.479

High

1256242

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

1314501

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

1340848

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.479

High

1143318

PLEC
Plectin

1

2

High-throughput

0.470

High

280880

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.464

High

1447765

ANM8
Protein arginine N-methyltransferase 8

1

2

High-throughput

0.464

High

354268

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

Small-scale

0.460

High

590121

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696960

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

755829

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.458

High

807634

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

1024960

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1128163

DHX8
ATP-dependent RNA helicase DHX8

1

0

High-throughput

0.458

High

1311927

SLF2
SMC5-SMC6 complex localization factor protein 2

1

0

High-throughput

0.458

High

1387661

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1458837

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

138542

BIN1
Myc box-dependent-interacting protein 1

1

1

High-throughput

0.457

High

1057069

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.457

High

387485

APOE
Apolipoprotein E

1

0

High-throughput

0.438

High

1060007

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.438

High

1347006

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.438

High

106910

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

255895

USO1
General vesicular transport factor p115

1

2

High-throughput

0.437

High

1063032

DDR1
Epithelial discoidin domain-containing receptor 1

1

2

High-throughput

0.437

High

1397889

KLH15
Kelch-like protein 15

1

0

High-throughput

0.426

High

1395436

NEUL4
Neuralized-like protein 4

2

0

High-throughput

0.313

High

961659

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.282

High

1215029

CPTP
Ceramide-1-phosphate transfer protein

1

0

High-throughput

0.282

High

423863

APOD
Apolipoprotein D

1

0

High-throughput

0.279

Low

1387806

MUCL1
Mucin-like protein 1

1

0

High-throughput

0.279

Low

1451346

F118A
Protein FAM118A

1

0

High-throughput

0.265

Low

165853

OPLA
5-oxoprolinase

1

0

High-throughput

0.251

Low

1180417

KLH40
Kelch-like protein 40

1

0

High-throughput

0.251

Low

1325332

PALS1
Protein PALS1

1

0

Small-scale

0.249

Low

1333381

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1461317

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low

251985

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025