HitPredict

Interactor 1: DNAL4 (O96015)
Dynein axonemal light chain 4
Gene: DNAL4

Interactor 2: DYL1 (P63167)
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)
Gene: DYNLL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid prey pooling approach, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Dynein_light~Dynein_light
Common GO terms	GO:0005737 - cytoplasm GO:0005874 - microtubule GO:0005886 - plasma membrane GO:0005929 - cilium GO:0030286 - dynein complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 105 Hs			1 89
+	Hs
		331173 DNAL4_HUMAN (1-105): 6.33e-45: 142: 100.00		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26
+	Dm
		1096023 DYL1_DROME (21-104): 8.43e-39: 126: 33.33		DYL1_DROME (1-89): 1.36e-46: 145: 94.38
+	Hs
		928254 DYL1_HUMAN (21-104): 1.27e-38: 125: 35.71		DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00
+	Ce
		1095042 DYL1_CAEEL (21-104): 2.34e-38: 125: 32.14		DYL1_CAEEL (1-89): 8.25e-46: 143: 92.14
+	Hs
		928427 DYL1_HUMAN (21-104): 1.27e-38: 125: 35.71		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26
+	Hs
		1291271 DYL2_HUMAN (21-104): 7.39e-38: 123: 33.33		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26
+	Hs
		331150 DNAL4_HUMAN (1-105): 6.33e-45: 142: 100.00		DNAL4_HUMAN (7-89): 1.89e-29: 102: 35.29
+	At
		1196448 Q84VW0_ARATH (19-104): 9.84e-36: 119: 33.72		Q9M810_ARATH (1-89): 3.77e-36: 119: 42.86
+	At
		1340184 Q9LW74_ARATH (21-105): 6.21e-34: 114: 29.07		Q9M810_ARATH (1-89): 3.77e-36: 119: 42.86
+	Sc
		971981 DYL1_YEAST (17-105): 7.59e-34: 113: 30.34		DYL1_YEAST (7-89): 8.74e-35: 115: 49.40