HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: RL23A (P62750)
Large ribosomal subunit protein uL23 (60S ribosomal protein L23a)
Gene: RPL23A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005730 - nucleolus GO:0005737 - cytoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 156
+	Hs
		916399 ASH1L_HUMAN (924-1232): 1.1e-57: 222: 31.75		RL23A_HUMAN (1-156): 1.41e-68: 206: 100.00
+	Hs
		916211 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		RL23A_HUMAN (1-156): 1.41e-68: 206: 100.00
+	Sc
		383135 SET1_YEAST (995-1203): 4.99e-62: 233: 31.11		RL25_YEAST (31-156): 1.38e-55: 172: 62.70
+	Sc
		383225 SET2_YEAST (972-1208): 9.39e-61: 225: 35.12		RL25_YEAST (31-156): 1.38e-55: 172: 62.70
+	Hs
		916151 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		RL23A_HUMAN (1-156): 1.41e-68: 206: 100.00
+	Hs
		916317 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		RL23A_HUMAN (1-156): 1.41e-68: 206: 100.00