HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 126
+	Hs
		331768 NSD2_HUMAN (1-1365): 0: 980: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		1087385 NSD3_HUMAN (116-1340): 0: 758: 45.19		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918663 NSD3_HUMAN (116-1340): 0: 758: 45.19		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707738 NSD3_HUMAN (116-1340): 0: 758: 45.19		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		203602 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		1274453 ASH1L_HUMAN (924-1232): 1.1e-57: 222: 31.75		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		1079994 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1080205 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		918389 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241535 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		1087410 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918699 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		1087341 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918611 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		1231227 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		1282965 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Sp
		223810 CLR4_SCHPO (947-1202): 5.1e-59: 214: 23.10		H2B1_SCHPO (4-125): 1.24e-45: 145: 70.49
+	Sc
		355890 SET1_YEAST (995-1203): 4.99e-62: 233: 31.11		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Hs
		1282945 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		241509 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41