HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.913

Property	Details
Experiments	7926767, 10372803, 11494134, 10967110, 17474147
Identification Methods	pull down, two hybrid, affinity chromatography technology, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0034976 - response to endoplasmic reticulum stress GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0046875 - ephrin receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 377
+	Mm
		337637 ABL1_MOUSE (1-1130): 0: 901: 85.00		NCK1_MOUSE (1-377): 7.48e-99: 300: 98.94
+	Hs
		337384 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		337466 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRAP_HUMAN (5-251): 9.35e-27: 107: 20.00
+	Hs
		298944 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		337356 ABL1_HUMAN (1-1130): 0: 984: 100.00		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129151 ABL1_HUMAN (1-1130): 0: 984: 100.00		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		337307 ABL1_HUMAN (1-1130): 0: 984: 100.00		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		337315 ABL1_HUMAN (1-1130): 0: 984: 100.00		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		557630 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		337329 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		337418 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		209001 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		69202 A9UF07_HUMAN (25-1130): 0: 945: 99.73		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		337526 ABL1_HUMAN (1-1130): 0: 984: 100.00		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Hs
		69198 A9UF07_HUMAN (25-1130): 0: 945: 99.73		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		69206 A9UF07_HUMAN (25-1130): 0: 945: 99.73		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		298959 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		412070 ABL2_HUMAN (10-1130): 0: 775: 52.62		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		442789 ABL2_HUMAN (10-1130): 0: 775: 52.62		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		522840 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32