Protein: PARN
Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)

Gene: PARN
Organism: Homo sapiens
Interactions: 126
UniProt ID: O95453

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000495 - box H/ACA sno(s)RNA 3'-end processing
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

337347

BYST
Bystin

4

0

High-throughput

0.670

High

337338

H11
Histone H1.1

3

5

High-throughput

0.667

High

337351

TEAD4
Transcriptional enhancer factor TEF-3

3

0

High-throughput

0.638

High

337304

ESR1
Estrogen receptor

3

2

High-throughput

0.633

High

337397

SLX9
Ribosome biogenesis protein SLX9 homolog

3

0

Small-scale

0.628

High

337301

PARN
Poly(A)-specific ribonuclease PARN

1

2

Small-scale

0.618

High

279256

TULP3
Tubby-related protein 3

2

0

High-throughput

0.602

High

337355

TSR1
Pre-rRNA-processing protein TSR1 homolog

2

0

High-throughput

0.602

High

337386

BARD1
BRCA1-associated RING domain protein 1

1

1

Small-scale

0.597

High

337369

CARME
Carnosine N-methyltransferase

2

0

High-throughput

0.585

High

337389

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

2

0

High-throughput

0.585

High

337331

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.559

High

337380

FUBP2
Far upstream element-binding protein 2

2

0

Small-scale

0.559

High

191502

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

290408

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

337310

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

337317

CSTF2
Cleavage stimulation factor subunit 2

1

1

Small-scale

0.536

High

337326

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

337330

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

337336

PRR3
Proline-rich protein 3

1

1

High-throughput

0.536

High

337337

SRSF2
Serine/arginine-rich splicing factor 2

1

1

High-throughput

0.536

High

337345

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.536

High

337370

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

337371

ZBT44
Zinc finger and BTB domain-containing protein 44

1

1

High-throughput

0.536

High

337414

RBM19
Probable RNA-binding protein 19

1

2

High-throughput

0.536

High

337341

NCBP1
Nuclear cap-binding protein subunit 1

1

0

Small-scale

0.527

High

337320

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

337328

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.513

High

337329

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

337353

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

0

High-throughput

0.513

High

337364

ZN677
Zinc finger protein 677

1

0

High-throughput

0.513

High

337366

DHX37
Probable ATP-dependent RNA helicase DHX37

1

0

High-throughput

0.513

High

337368

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

337374

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.513

High

337376

DOK4
Docking protein 4

1

0

High-throughput

0.513

High

337377

ANR49
Ankyrin repeat domain-containing protein 49

1

0

High-throughput

0.513

High

337387

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.513

High

337390

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.513

High

337398

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

337408

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

337412

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.513

High

337324

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

337350

UBE3C
Ubiquitin-protein ligase E3C

1

1

High-throughput

0.489

High

337393

SPC1L
Speriolin-like protein

1

0

High-throughput

0.486

High

337311

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

337321

MAPK2
MAP kinase-activated protein kinase 2

1

0

Small-scale

0.480

High

128695

MEN1
Menin

1

1

High-throughput

0.479

High

190778

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

240377

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

272589

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

1

High-throughput

0.479

High

278196

NCOR1
Nuclear receptor corepressor 1

1

2

High-throughput

0.479

High

337302

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

337306

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

337307

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.479

High

337309

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

337315

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.479

High

337316

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

337322

RBM5
RNA-binding protein 5

1

2

High-throughput

0.479

High

337327

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

337333

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

337334

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.479

High

337335

H31
Histone H3.1

1

1

High-throughput

0.479

High

337339

CSTF1
Cleavage stimulation factor subunit 1

1

2

Small-scale

0.479

High

337342

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

337343

ILF3
Interleukin enhancer-binding factor 3

1

1

High-throughput

0.479

High

337344

CSTF3
Cleavage stimulation factor subunit 3

1

2

High-throughput

0.479

High

337358

BCOR
BCL-6 corepressor

1

1

High-throughput

0.479

High

337359

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

337361

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

337363

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.479

High

337372

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

337373

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

337375

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

1

High-throughput

0.479

High

337383

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

High-throughput

0.479

High

337392

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

3

High-throughput

0.479

High

337396

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

337405

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

337410

YETS2
YEATS domain-containing protein 2

1

1

High-throughput

0.479

High

337411

RL26L
Ribosomal protein uL24-like

1

1

High-throughput

0.479

High

337415

NCOR2
Nuclear receptor corepressor 2

1

1

High-throughput

0.479

High

140697

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

259258

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

337303

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

337308

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

337313

PABP1
Polyadenylate-binding protein 1

1

0

Small-scale

0.458

High

337314

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

337319

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

337323

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

337325

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

337332

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

337346

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.458

High

337348

NBR1
Next to BRCA1 gene 1 protein

1

0

Small-scale

0.458

High

337349

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.458

High

337357

RRP12
RRP12-like protein

1

0

High-throughput

0.458

High

337362

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

337365

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

337378

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

337379

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

337381

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

337382

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.458

High

337384

GWL
Serine/threonine-protein kinase greatwall

1

0

High-throughput

0.458

High

337388

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

337391

NADAP
Kanadaptin

1

0

High-throughput

0.458

High

337394

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

337395

RENT2
Regulator of nonsense transcripts 2

1

0

Small-scale

0.458

High

337399

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.458

High

337400

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

337403

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

337404

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

337406

TRPS1
Zinc finger transcription factor Trps1

1

0

High-throughput

0.458

High

337407

DACH1
Dachshund homolog 1

1

0

High-throughput

0.458

High

337409

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

337413

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

337305

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

337385

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.438

High

337318

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

337356

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

337340

PIGF
GPI ethanolamine phosphate transferase, stabilizing subunit

1

0

High-throughput

0.279

Low

337360

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.279

Low

337367

LGI2
Leucine-rich repeat LGI family member 2

1

0

High-throughput

0.279

Low

337401

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

0

High-throughput

0.279

Low

337402

PALS2
Protein PALS2

1

0

High-throughput

0.251

Low

337312

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

0

High-throughput

0.249

Low

337352

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.249

Low

337354

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025